Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4369423..4369999 Replicon chromosome
Accession NZ_CP122600
Organism Escherichia coli strain ETEC6333

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag QDX83_RS21545 Protein ID WP_001297643.1
Coordinates 4369712..4369999 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A080I7H7
Locus tag QDX83_RS21540 Protein ID WP_000063160.1
Coordinates 4369423..4369725 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDX83_RS21525 (4366019) 4366019..4368169 + 2151 WP_001295524.1 pyruvate/proton symporter BtsT -
QDX83_RS21530 (4368219) 4368219..4368422 + 204 WP_000467859.1 YbdD/YjiX family protein -
QDX83_RS21535 (4368433) 4368433..4369389 + 957 WP_001297640.1 GTPase -
QDX83_RS21540 (4369423) 4369423..4369725 - 303 WP_000063160.1 BrnA antitoxin family protein Antitoxin
QDX83_RS21545 (4369712) 4369712..4369999 - 288 WP_001297643.1 BrnT family toxin Toxin
QDX83_RS21550 (4370198) 4370198..4370895 - 698 Protein_4220 IS1 family transposase -
QDX83_RS21555 (4370952) 4370952..4371047 + 96 Protein_4221 dienelactone hydrolase family protein -
QDX83_RS21560 (4371193) 4371193..4372425 + 1233 WP_024186283.1 multidrug efflux MFS transporter MdtM -
QDX83_RS21565 (4372466) 4372466..4373746 + 1281 WP_001037400.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T277290 WP_001297643.1 NZ_CP122600:c4369999-4369712 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11552.01 Da        Isoelectric Point: 9.4646

>AT277290 WP_000063160.1 NZ_CP122600:c4369725-4369423 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALTNKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GEV9

Antitoxin

Source ID Structure
AlphaFold DB A0A080I7H7

References