Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 829008..829668 Replicon chromosome
Accession NC_017845
Organism Pectobacterium sp. SCC3193

Toxin (Protein)


Gene name cptA Uniprot ID A0A8B3EZX7
Locus tag W5S_RS03730 Protein ID WP_012822581.1
Coordinates 829255..829668 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0H3I0G9
Locus tag W5S_RS03725 Protein ID WP_012822580.1
Coordinates 829008..829274 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
W5S_RS03705 825000..826004 - 1005 WP_014698755.1 substrate-binding domain-containing protein -
W5S_RS03710 826058..826666 - 609 WP_014698756.1 HD domain-containing protein -
W5S_RS03715 827077..827724 + 648 WP_012822578.1 hemolysin III family protein -
W5S_RS03720 827779..828780 - 1002 WP_012822579.1 tRNA-modifying protein YgfZ -
W5S_RS03725 829008..829274 + 267 WP_012822580.1 FAD assembly factor SdhE Antitoxin
W5S_RS03730 829255..829668 + 414 WP_012822581.1 protein YgfX Toxin
W5S_RS03735 829894..830829 + 936 WP_014698758.1 23S rRNA (adenine(1618)-N(6))-methyltransferase RlmF -
W5S_RS03740 830917..831240 - 324 WP_012822583.1 hypothetical protein -
W5S_RS03745 831269..831787 - 519 WP_012822584.1 flavodoxin FldB -
W5S_RS03750 832115..833131 + 1017 WP_012822585.1 methionine ABC transporter ATP-binding protein -
W5S_RS03755 833124..833792 + 669 WP_012822586.1 ABC transporter permease -
W5S_RS03760 833810..834628 + 819 WP_043898944.1 MetQ/NlpA family ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-132)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16259.20 Da        Isoelectric Point: 10.7923

>T27729 WP_012822581.1 NC_017845:829255-829668 [Pectobacterium parmentieri]
VAQWQCDLRVSWRMQLLSLVVHGLLVLLILLAPWPDGYAWLWLCLVTMVMFGFIRSQRNIKSRQGCITLLSETTLNWRQQ
EWRIVKRPWLLKNGVLLALQSANGKDKQQLWLASDSMGDDEWRHLRQLLLQQKHWAR

Download         Length: 414 bp

>T27729 NC_017845:829255-829668 [Pectobacterium parmentieri]
GTGGCCCAGTGGCAATGTGACCTTCGCGTTTCCTGGCGCATGCAACTGCTGTCATTGGTTGTGCATGGTCTATTAGTGTT
GCTCATTCTGCTGGCACCGTGGCCGGACGGCTATGCGTGGCTGTGGCTGTGTTTGGTCACAATGGTGATGTTTGGTTTCA
TCCGTAGCCAAAGGAATATCAAATCGCGGCAAGGGTGCATCACGCTGCTCAGCGAAACGACCCTGAACTGGCGGCAGCAG
GAGTGGCGGATTGTCAAACGACCGTGGTTGCTGAAAAATGGTGTGTTATTGGCATTGCAATCGGCTAATGGGAAAGACAA
GCAACAACTGTGGCTGGCATCGGACAGTATGGGCGATGACGAATGGCGTCATCTGCGCCAGCTTCTTTTGCAGCAAAAAC
ACTGGGCGAGATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10519.99 Da        Isoelectric Point: 5.1392

>AT27729 WP_012822580.1 NC_017845:829008-829274 [Pectobacterium parmentieri]
MEIDNKSRIHWACRRGMRELDIAIMPFFEHDYDTLNDIDKRTFVRLLQSDDPDLFNWLMNHGEPEDGELKRMISLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT27729 NC_017845:829008-829274 [Pectobacterium parmentieri]
ATGGAAATCGATAACAAATCACGTATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTGGATATCGCCATCATGCCGTT
TTTTGAGCATGACTATGACACATTAAACGATATAGATAAGCGCACGTTTGTACGCCTGCTACAAAGCGACGATCCCGATT
TATTCAACTGGCTAATGAACCACGGTGAGCCAGAAGACGGAGAGCTAAAACGCATGATTTCCCTTATCCAGACGCGAAAT
AAAGATCGTGGCCCAGTGGCAATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B3EZX7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3I0G9

References