Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 18509..19110 Replicon plasmid unnamed9
Accession NZ_CP122597
Organism Escherichia coli strain ETEC6335

Toxin (Protein)


Gene name doc Uniprot ID U9YA20
Locus tag QDY30_RS27830 Protein ID WP_001216045.1
Coordinates 18509..18889 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag QDY30_RS27835 Protein ID WP_001190712.1
Coordinates 18889..19110 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY30_RS27805 (QDY30_27815) 13950..15434 - 1485 WP_000124150.1 terminase -
QDY30_RS27810 (QDY30_27820) 15434..16627 - 1194 WP_096321055.1 terminase -
QDY30_RS27815 (QDY30_27825) 16713..17165 - 453 WP_001326849.1 late promoter-activating protein -
QDY30_RS27820 (QDY30_27830) 17254..18297 - 1044 WP_069187067.1 DUF968 domain-containing protein -
QDY30_RS27825 (QDY30_27835) 18325..18504 - 180 WP_001339207.1 hypothetical protein -
QDY30_RS27830 (QDY30_27840) 18509..18889 - 381 WP_001216045.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
QDY30_RS27835 (QDY30_27845) 18889..19110 - 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QDY30_RS27840 (QDY30_27850) 19293..20849 + 1557 WP_096314329.1 type I restriction-modification system subunit M -
QDY30_RS27845 (QDY30_27855) 20846..22054 + 1209 WP_106108225.1 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..92714 92714


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13588.29 Da        Isoelectric Point: 5.1514

>T277270 WP_001216045.1 NZ_CP122597:c18889-18509 [Escherichia coli]
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT277270 WP_001190712.1 NZ_CP122597:c19110-18889 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CLP7

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References