Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1..593 Replicon plasmid unnamed8
Accession NZ_CP122596
Organism Escherichia coli strain ETEC6335

Toxin (Protein)


Gene name hicA Uniprot ID V0AGQ2
Locus tag QDY30_RS27525 Protein ID WP_000520549.1
Coordinates 1..249 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID V0AWG0
Locus tag QDY30_RS27530 Protein ID WP_000681613.1
Coordinates 246..593 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY30_RS27525 (QDY30_27535) 1..249 + 249 WP_000520549.1 type II toxin-antitoxin system HicA family toxin Toxin
QDY30_RS27530 (QDY30_27540) 246..593 + 348 WP_000681613.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QDY30_RS27535 (QDY30_27545) 954..1454 + 501 WP_063270188.1 DNA distortion polypeptide 1 -
QDY30_RS27540 (QDY30_27550) 1466..2695 + 1230 WP_001694183.1 DNA relaxase/nickase TaxC -
QDY30_RS27545 (QDY30_27555) 2772..3038 + 267 WP_000160396.1 hypothetical protein -
QDY30_RS27550 (QDY30_27560) 3043..3276 + 234 WP_000121162.1 EexN family lipoprotein -
QDY30_RS27555 (QDY30_27565) 3640..4260 + 621 WP_001694184.1 lytic transglycosylase domain-containing protein -
QDY30_RS27560 (QDY30_27570) 4274..4600 + 327 WP_000008647.1 TrbC/VirB2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..34112 34112


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9422.08 Da        Isoelectric Point: 10.4800

>T277269 WP_000520549.1 NZ_CP122596:1-249 [Escherichia coli]
MGKTDKLLAKFLNSKKTFEWDELVVLFSSLGYVKKEMQGSRVRFFNAEINHTILMHRPHPESYIKGGTLKAIKQNLKEAG
LL

Download         Length: 249 bp

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13113.84 Da        Isoelectric Point: 4.6723

>AT277269 WP_000681613.1 NZ_CP122596:246-593 [Escherichia coli]
MKHLKYKGYLGTVEPDFENNVLYGKLAFIRDLVTYEASTLAELEQEFKTSVDLYLQSCVEDGKEPDTPFKGVFNVRLDPE
LHRRVAEMAMEEDLSLNAFVNKALEKEVSNHRAGA

Download         Length: 348 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CIX3

Antitoxin

Source ID Structure
AlphaFold DB A0A829CLC1

References