Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 62710..63269 Replicon plasmid unnamed4
Accession NZ_CP122592
Organism Escherichia coli strain ETEC6335

Toxin (Protein)


Gene name relE Uniprot ID S1PMX5
Locus tag QDY30_RS26120 Protein ID WP_000421257.1
Coordinates 62994..63269 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C1J8K5
Locus tag QDY30_RS26115 Protein ID WP_001178089.1
Coordinates 62710..62994 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY30_RS26085 (58482) 58482..59072 + 591 WP_012817838.1 DUF2726 domain-containing protein -
QDY30_RS26090 (59227) 59227..59691 + 465 WP_000872610.1 hypothetical protein -
QDY30_RS26095 (59948) 59948..60097 + 150 WP_001378818.1 Hok/Gef family protein -
QDY30_RS26100 (60381) 60381..60629 + 249 WP_000083839.1 replication regulatory protein RepA -
QDY30_RS26105 (60873) 60873..60947 + 75 WP_001365705.1 RepA leader peptide Tap -
QDY30_RS26110 (60940) 60940..61797 + 858 WP_012817826.1 incFII family plasmid replication initiator RepA -
QDY30_RS26115 (62710) 62710..62994 + 285 WP_001178089.1 ribbon-helix-helix domain-containing protein Antitoxin
QDY30_RS26120 (62994) 62994..63269 + 276 WP_000421257.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QDY30_RS26125 (63552) 63552..64739 - 1188 WP_000937591.1 IS91 family transposase -
QDY30_RS26130 (64739) 64739..65104 - 366 WP_000091308.1 hypothetical protein -
QDY30_RS26135 (65381) 65381..66568 - 1188 WP_116794643.1 IS91-like element IS91 family transposase -
QDY30_RS26140 (66568) 66568..66933 - 366 WP_000124098.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - hlyC / hlyA / hlyB / hlyB / hlyD / estIa 1..120805 120805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10749.45 Da        Isoelectric Point: 9.9324

>T277264 WP_000421257.1 NZ_CP122592:62994-63269 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR

Download         Length: 276 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10456.86 Da        Isoelectric Point: 5.6558

>AT277264 WP_001178089.1 NZ_CP122592:62710-62994 [Escherichia coli]
IQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PMX5

Antitoxin

Source ID Structure
AlphaFold DB A0A731IHA8

References