Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 109818..110461 Replicon plasmid unnamed1
Accession NZ_CP122589
Organism Escherichia coli strain ETEC6335

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag QDY30_RS25465 Protein ID WP_001044768.1
Coordinates 109818..110234 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D2WFK3
Locus tag QDY30_RS25470 Protein ID WP_001261287.1
Coordinates 110231..110461 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY30_RS25450 (106317) 106317..106907 - 591 WP_000194575.1 hypothetical protein -
QDY30_RS25455 (106907) 106907..107164 - 258 WP_000343085.1 hypothetical protein -
QDY30_RS25460 (107518) 107518..109656 + 2139 WP_000350639.1 AAA family ATPase -
QDY30_RS25465 (109818) 109818..110234 - 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
QDY30_RS25470 (110231) 110231..110461 - 231 WP_001261287.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QDY30_RS25475 (110757) 110757..111047 + 291 WP_000111771.1 hypothetical protein -
QDY30_RS25480 (111037) 111037..111936 + 900 WP_000963206.1 nucleotide-binding protein -
QDY30_RS25485 (111986) 111986..114211 - 2226 WP_000698737.1 P-loop NTPase fold protein -
QDY30_RS25490 (114213) 114213..115301 - 1089 WP_000952217.1 transcriptional repressor PifC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sul1 / qacE / ant(3'')-Ia / dfrA1 / tet(A) - 1..136050 136050


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15197.66 Da        Isoelectric Point: 7.7805

>T277260 WP_001044768.1 NZ_CP122589:c110234-109818 [Escherichia coli]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8815.90 Da        Isoelectric Point: 4.3775

>AT277260 WP_001261287.1 NZ_CP122589:c110461-110231 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A606Q844

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QFC4

References