Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4603360..4603869 Replicon chromosome
Accession NZ_CP122588
Organism Escherichia coli strain ETEC6335

Toxin (Protein)


Gene name ghoT Uniprot ID -
Locus tag QDY30_RS22520 Protein ID WP_282865733.1
Coordinates 4603360..4603545 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag QDY30_RS22525 Protein ID WP_000398619.1
Coordinates 4603573..4603869 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY30_RS22510 (4600043) 4600043..4601500 + 1458 WP_119457808.1 dipeptide/tripeptide permease DtpC -
QDY30_RS22515 (4601737) 4601737..4603254 + 1518 WP_001295074.1 lysine--tRNA ligase -
QDY30_RS22520 (4603360) 4603360..4603545 - 186 WP_282865733.1 type V toxin-antitoxin system toxin GhoT Toxin
QDY30_RS22525 (4603573) 4603573..4603869 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QDY30_RS22530 (4604096) 4604096..4604368 - 273 WP_175062327.1 GNAT family N-acetyltransferase -
QDY30_RS22535 (4604581) 4604581..4607733 - 3153 WP_282865737.1 autotransporter outer membrane beta-barrel domain-containing protein -
QDY30_RS22540 (4607687) 4607687..4608508 - 822 WP_282865739.1 S6 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - espC 4603360..4619594 16234


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-54)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 7002.57 Da        Isoelectric Point: 10.2380

>T277255 WP_282865733.1 NZ_CP122588:c4603545-4603360 [Escherichia coli]
MALFSKILIFYVIGVNISFIIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFLSFRSCS

Download         Length: 186 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT277255 WP_000398619.1 NZ_CP122588:c4603869-4603573 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References