Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4506241..4506836 Replicon chromosome
Accession NZ_CP122588
Organism Escherichia coli strain ETEC6335

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag QDY30_RS22020 Protein ID WP_000239579.1
Coordinates 4506241..4506591 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag QDY30_RS22025 Protein ID WP_001223208.1
Coordinates 4506585..4506836 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY30_RS22000 (4501687) 4501687..4502709 - 1023 WP_075842764.1 ABC transporter permease -
QDY30_RS22005 (4502723) 4502723..4504225 - 1503 WP_028132188.1 sugar ABC transporter ATP-binding protein -
QDY30_RS22010 (4504365) 4504365..4505321 - 957 WP_000265942.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
QDY30_RS22015 (4505631) 4505631..4506161 + 531 WP_000055072.1 inorganic diphosphatase -
QDY30_RS22020 (4506241) 4506241..4506591 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
QDY30_RS22025 (4506585) 4506585..4506836 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
QDY30_RS22030 (4507048) 4507048..4507389 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
QDY30_RS22035 (4507392) 4507392..4511171 - 3780 WP_053274060.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T277254 WP_000239579.1 NZ_CP122588:c4506591-4506241 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT277254 WP_001223208.1 NZ_CP122588:c4506836-4506585 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References