Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4398319..4398895 Replicon chromosome
Accession NZ_CP122588
Organism Escherichia coli strain ETEC6335

Toxin (Protein)


Gene name shpA Uniprot ID A0A061KXE4
Locus tag QDY30_RS21545 Protein ID WP_001295743.1
Coordinates 4398608..4398895 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID -
Locus tag QDY30_RS21540 Protein ID WP_119457955.1
Coordinates 4398319..4398621 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY30_RS21520 (4394010) 4394010..4394522 + 513 WP_001175455.1 4-hydroxyphenylacetate 3-monooxygenase reductase subunit -
QDY30_RS21525 (4394915) 4394915..4397065 + 2151 WP_001309197.1 pyruvate/proton symporter BtsT -
QDY30_RS21530 (4397115) 4397115..4397318 + 204 WP_000467859.1 YbdD/YjiX family protein -
QDY30_RS21535 (4397329) 4397329..4398285 + 957 WP_001297640.1 GTPase -
QDY30_RS21540 (4398319) 4398319..4398621 - 303 WP_119457955.1 BrnA antitoxin family protein Antitoxin
QDY30_RS21545 (4398608) 4398608..4398895 - 288 WP_001295743.1 BrnT family toxin Toxin
QDY30_RS21550 (4399092) 4399092..4400258 + 1167 WP_047623658.1 restriction endonuclease -
QDY30_RS21555 (4400322) 4400322..4401941 + 1620 WP_033814747.1 class I SAM-dependent DNA methyltransferase -
QDY30_RS21560 (4401931) 4401931..4403310 + 1380 WP_033814748.1 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11156.62 Da        Isoelectric Point: 7.4697

>T277253 WP_001295743.1 NZ_CP122588:c4398895-4398608 [Escherichia coli]
MPMEFEWDANKAKSNRVKHGIRFEDAVLVFDDPQHLSQQDRIENGEYRWQTIGLVHGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERSRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11512.04 Da        Isoelectric Point: 9.4646

>AT277253 WP_119457955.1 NZ_CP122588:c4398621-4398319 [Escherichia coli]
MSMVKHKRGAPPTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061KXE4

Antitoxin

Source ID Structure

References