Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 4160636..4161107 Replicon chromosome
Accession NZ_CP122588
Organism Escherichia coli strain ETEC6335

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag QDY30_RS20400 Protein ID WP_001303511.1
Coordinates 4160829..4161107 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag QDY30_RS20395 Protein ID WP_001302048.1
Coordinates 4160636..4160827 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY30_RS20350 (4155900) 4155900..4156430 - 531 WP_151316972.1 DUF551 domain-containing protein -
QDY30_RS20355 (4156432) 4156432..4156650 - 219 WP_151316973.1 DUF4014 family protein -
QDY30_RS20360 (4156745) 4156745..4156945 - 201 WP_282866826.1 hypothetical protein -
QDY30_RS20365 (4156932) 4156932..4157675 - 744 WP_063101778.1 DUF1627 domain-containing protein -
QDY30_RS20370 (4157698) 4157698..4158444 - 747 WP_000788975.1 ATP-binding protein -
QDY30_RS20375 (4158451) 4158451..4159398 - 948 WP_063082131.1 helix-turn-helix domain-containing protein -
QDY30_RS20380 (4159422) 4159422..4159847 - 426 WP_000693861.1 toxin YdaT family protein -
QDY30_RS20385 (4159844) 4159844..4160146 - 303 WP_000172735.1 transcriptional regulator -
QDY30_RS20390 (4160244) 4160244..4160615 + 372 WP_001169685.1 hypothetical protein -
QDY30_RS20395 (4160636) 4160636..4160827 + 192 WP_001302048.1 hypothetical protein Antitoxin
QDY30_RS20400 (4160829) 4160829..4161107 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QDY30_RS20405 (4161406) 4161406..4161612 + 207 WP_001171935.1 hypothetical protein -
QDY30_RS20410 (4161637) 4161637..4162275 + 639 WP_033813300.1 hypothetical protein -
QDY30_RS20415 (4162276) 4162276..4162485 - 210 WP_033813301.1 hypothetical protein -
QDY30_RS20420 (4163054) 4163054..4163242 + 189 WP_089565158.1 cell division inhibition protein DicB -
QDY30_RS20425 (4163239) 4163239..4163442 + 204 WP_053289477.1 DUF1482 family protein -
QDY30_RS20430 (4163523) 4163523..4166006 + 2484 WP_096937579.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4157698..4167402 9704


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T277251 WP_001303511.1 NZ_CP122588:4160829-4161107 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT277251 WP_001302048.1 NZ_CP122588:4160636-4160827 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References