Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3753861..3754479 Replicon chromosome
Accession NZ_CP122588
Organism Escherichia coli strain ETEC6335

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QDY30_RS18340 Protein ID WP_001291435.1
Coordinates 3754261..3754479 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QDY30_RS18335 Protein ID WP_000344800.1
Coordinates 3753861..3754235 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY30_RS18325 (3748950) 3748950..3750143 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QDY30_RS18330 (3750166) 3750166..3753315 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QDY30_RS18335 (3753861) 3753861..3754235 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QDY30_RS18340 (3754261) 3754261..3754479 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QDY30_RS18345 (3754651) 3754651..3755202 + 552 WP_000102564.1 maltose O-acetyltransferase -
QDY30_RS18350 (3755318) 3755318..3755788 + 471 WP_000136192.1 YlaC family protein -
QDY30_RS18355 (3755952) 3755952..3757502 + 1551 WP_119457962.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QDY30_RS18360 (3757544) 3757544..3757897 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QDY30_RS18370 (3758276) 3758276..3758587 + 312 WP_000409911.1 MGMT family protein -
QDY30_RS18375 (3758618) 3758618..3759190 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T277249 WP_001291435.1 NZ_CP122588:3754261-3754479 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT277249 WP_000344800.1 NZ_CP122588:3753861-3754235 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References