Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2569618..2570256 Replicon chromosome
Accession NZ_CP122588
Organism Escherichia coli strain ETEC6335

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag QDY30_RS12555 Protein ID WP_000813794.1
Coordinates 2570080..2570256 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QDY30_RS12550 Protein ID WP_001270286.1
Coordinates 2569618..2570034 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY30_RS12530 (2564770) 2564770..2565711 - 942 WP_001251315.1 ABC transporter permease -
QDY30_RS12535 (2565712) 2565712..2566725 - 1014 WP_134795749.1 ABC transporter ATP-binding protein -
QDY30_RS12540 (2566743) 2566743..2567888 - 1146 WP_119458051.1 ABC transporter substrate-binding protein -
QDY30_RS12545 (2568133) 2568133..2569539 - 1407 WP_000760666.1 PLP-dependent aminotransferase family protein -
QDY30_RS12550 (2569618) 2569618..2570034 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
QDY30_RS12555 (2570080) 2570080..2570256 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
QDY30_RS12560 (2570478) 2570478..2570708 + 231 WP_000494244.1 YncJ family protein -
QDY30_RS12565 (2570800) 2570800..2572761 - 1962 WP_119458050.1 23S rRNA 5-hydroxycytidine C2501 synthase -
QDY30_RS12570 (2572834) 2572834..2573370 - 537 WP_000429152.1 DNA-binding transcriptional regulator SutR -
QDY30_RS12575 (2573462) 2573462..2574637 + 1176 WP_062883094.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2574677..2575825 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T277244 WP_000813794.1 NZ_CP122588:c2570256-2570080 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT277244 WP_001270286.1 NZ_CP122588:c2570034-2569618 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References