Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2474655..2476243 Replicon chromosome
Accession NZ_CP122588
Organism Escherichia coli strain ETEC6335

Toxin (Protein)


Gene name hipA Uniprot ID A0A085NXE9
Locus tag QDY30_RS12155 Protein ID WP_044191965.1
Coordinates 2474921..2476243 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A2S8JJP6
Locus tag QDY30_RS12150 Protein ID WP_064226053.1
Coordinates 2474655..2474921 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY30_RS12150 (2474655) 2474655..2474921 + 267 WP_064226053.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QDY30_RS12155 (2474921) 2474921..2476243 + 1323 WP_044191965.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
QDY30_RS12160 (2476514) 2476514..2476783 + 270 Protein_2381 AraC family transcriptional regulator -
QDY30_RS12165 (2477217) 2477217..2477780 + 564 WP_001296758.1 type 1 fimbrial major subunit FimA -
QDY30_RS12170 (2478141) 2478141..2478851 + 711 WP_001195165.1 fimbria/pilus periplasmic chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49365.00 Da        Isoelectric Point: 8.5823

>T277243 WP_044191965.1 NZ_CP122588:2474921-2476243 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10017.36 Da        Isoelectric Point: 4.9632

>AT277243 WP_064226053.1 NZ_CP122588:2474655-2474921 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085NXE9

Antitoxin

Source ID Structure
AlphaFold DB A0A2S8JJP6

References