Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1240753..1241433 Replicon chromosome
Accession NZ_CP122588
Organism Escherichia coli strain ETEC6335

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag QDY30_RS06050 Protein ID WP_175087257.1
Coordinates 1240753..1241073 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag QDY30_RS06055 Protein ID WP_175087259.1
Coordinates 1241110..1241433 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY30_RS06045 (1235855) 1235855..1240435 + 4581 WP_175087255.1 adhesin-like autotransporter YpjA/EhaD -
QDY30_RS06050 (1240753) 1240753..1241073 - 321 WP_175087257.1 TA system toxin CbtA family protein Toxin
QDY30_RS06055 (1241110) 1241110..1241433 - 324 WP_175087259.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QDY30_RS06060 (1241466) 1241466..1241936 - 471 WP_175087261.1 DNA repair protein RadC -
QDY30_RS06065 (1242006) 1242006..1242824 - 819 WP_175087262.1 DUF932 domain-containing protein -
QDY30_RS06070 (1243227) 1243227..1243898 + 672 WP_175087264.1 inovirus Gp2 family protein -
QDY30_RS06075 (1244213) 1244213..1245625 + 1413 WP_282866286.1 YfjI family protein -
QDY30_RS06080 (1245890) 1245890..1246168 + 279 WP_077902735.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1233525..1252753 19228


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(5-105)

Antitoxin

Antitoxin CbeA

(7-106)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12056.72 Da        Isoelectric Point: 6.3221

>T277237 WP_175087257.1 NZ_CP122588:c1241073-1240753 [Escherichia coli]
MHISTVPATVPVSSRLSPVQVWQQLLTYLLEHHYGLTLNDTPFHDNTAIEEHIDAGIKLVDAVNFLVERYELVRIDRKGF
SWQDQTPFLSATDILRARRATGIIST

Download         Length: 321 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11980.63 Da        Isoelectric Point: 6.7054

>AT277237 WP_175087259.1 NZ_CP122588:c1241433-1241110 [Escherichia coli]
MSLSDSPQWGLQSDITPRFGARLVQEGKRLHYLADRAGLTGGFTPEQLQKLDQTFPLFIDQLESMLRSGELNPKQQHQVN
IHLTGLTCIADTRGSCGYVYISIYLTP

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References