Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 762231..763068 Replicon chromosome
Accession NZ_CP122588
Organism Escherichia coli strain ETEC6335

Toxin (Protein)


Gene name yeeV Uniprot ID A0A7U9LL67
Locus tag QDY30_RS03735 Protein ID WP_000854687.1
Coordinates 762688..763068 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag QDY30_RS03730 Protein ID WP_012816826.1
Coordinates 762231..762599 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY30_RS03695 (758418) 758418..759095 + 678 WP_024226808.1 hypothetical protein -
QDY30_RS03700 (759111) 759111..759521 + 411 WP_000848829.1 hypothetical protein -
QDY30_RS03705 (759741) 759741..760562 + 822 WP_001234566.1 DUF932 domain-containing protein -
QDY30_RS03710 (760562) 760562..760807 + 246 WP_000680588.1 hypothetical protein -
QDY30_RS03715 (760901) 760901..761374 + 474 WP_001364892.1 antirestriction protein -
QDY30_RS03720 (761390) 761390..761866 + 477 WP_001364966.1 RadC family protein -
QDY30_RS03725 (761935) 761935..762156 + 222 WP_000692340.1 DUF987 domain-containing protein -
QDY30_RS03730 (762231) 762231..762599 + 369 WP_012816826.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QDY30_RS03735 (762688) 762688..763068 + 381 WP_000854687.1 TA system toxin CbtA family protein Toxin
QDY30_RS03740 (763065) 763065..763553 + 489 WP_001054227.1 DUF5983 family protein -
QDY30_RS03745 (763573) 763573..763770 + 198 WP_000772026.1 DUF957 domain-containing protein -
QDY30_RS03750 (763855) 763855..764700 + 846 WP_001274558.1 DUF4942 domain-containing protein -
QDY30_RS03760 (765000) 765000..765506 + 507 WP_000228930.1 G/U mismatch-specific DNA glycosylase -
QDY30_RS03765 (765585) 765585..767426 - 1842 WP_000437371.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14199.13 Da        Isoelectric Point: 6.8615

>T277235 WP_000854687.1 NZ_CP122588:762688-763068 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFSDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGVPSQLINSIDILRARRATGLMTRDNYRTVNNITLGRHPEEAKQ

Download         Length: 381 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13780.56 Da        Isoelectric Point: 6.4763

>AT277235 WP_012816826.1 NZ_CP122588:762231-762599 [Escherichia coli]
VSDTLHETNYPNDNHNRPWWGLPCTVTPCFGARLVQEGNRLHYLDDRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVALYAKGLTCDADTLGSCGYVYLAVYPTPDMKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LL67

Antitoxin

Source ID Structure

References