Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 301188..301819 Replicon chromosome
Accession NZ_CP122588
Organism Escherichia coli strain ETEC6335

Toxin (Protein)


Gene name hicA Uniprot ID A0A7U9LJQ2
Locus tag QDY30_RS01330 Protein ID WP_001259387.1
Coordinates 301188..301463 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag QDY30_RS01335 Protein ID WP_000593555.1
Coordinates 301460..301819 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY30_RS01315 (296192) 296192..297259 + 1068 WP_119457861.1 HlyD family secretion protein -
QDY30_RS01320 (297256) 297256..299991 + 2736 WP_000149129.1 ribosome-associated ATPase/putative transporter RbbA -
QDY30_RS01325 (299991) 299991..301115 + 1125 WP_001314210.1 ABC transporter permease -
QDY30_RS01330 (301188) 301188..301463 + 276 WP_001259387.1 type II toxin-antitoxin system HicA family toxin Toxin
QDY30_RS01335 (301460) 301460..301819 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QDY30_RS01340 (301869) 301869..302729 - 861 WP_001131788.1 class II aldolase -
QDY30_RS01345 (302761) 302761..303030 - 270 WP_000933061.1 HPr family phosphocarrier protein -
QDY30_RS01350 (303020) 303020..304528 - 1509 WP_001298718.1 FGGY-family carbohydrate kinase -
QDY30_RS01355 (304521) 304521..305879 - 1359 WP_001308116.1 PTS galactitol transporter subunit IIC -
QDY30_RS01360 (305956) 305956..306237 - 282 WP_000084022.1 PTS sugar transporter subunit IIB -
QDY30_RS01365 (306234) 306234..306707 - 474 WP_097484260.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 292332..301819 9487


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10214.91 Da        Isoelectric Point: 10.7076

>T277233 WP_001259387.1 NZ_CP122588:301188-301463 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESQVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT277233 WP_000593555.1 NZ_CP122588:301460-301819 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LJQ2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References