Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4978203..4979884 Replicon chromosome
Accession NZ_CP122587
Organism Klebsiella pneumoniae strain NCRE-61

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag QDV36_RS28910 Protein ID WP_002885155.1
Coordinates 4978203..4979120 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag QDV36_RS28915 Protein ID WP_004151732.1
Coordinates 4979126..4979884 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDV36_RS28890 (QDV36_28905) 4973509..4975029 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
QDV36_RS28895 (QDV36_28910) 4975026..4976024 + 999 WP_002885172.1 ribose ABC transporter permease -
QDV36_RS28900 (QDV36_28915) 4976055..4976996 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
QDV36_RS28905 (QDV36_28920) 4977071..4978078 + 1008 WP_004151731.1 carbohydrate kinase family protein -
QDV36_RS28910 (QDV36_28925) 4978203..4979120 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
QDV36_RS28915 (QDV36_28930) 4979126..4979884 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
QDV36_RS28920 (QDV36_28935) 4979970..4980698 - 729 WP_002885152.1 response regulator transcription factor -
QDV36_RS28925 (QDV36_28940) 4980971..4983118 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
QDV36_RS28930 (QDV36_28945) 4983348..4984034 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T277231 WP_002885155.1 NZ_CP122587:c4979120-4978203 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT277231 WP_004151732.1 NZ_CP122587:c4979884-4979126 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References