277227

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2813817..2815405 Replicon chromosome
Accession NZ_CP122587
Organism Klebsiella pneumoniae strain NCRE-61

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag QDV36_RS18185 Protein ID WP_004199851.1
Coordinates 2813817..2815139 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag QDV36_RS18190 Protein ID WP_002904790.1
Coordinates 2815139..2815405 (-) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDV36_RS18170 (QDV36_18175) 2808882..2811383 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
QDV36_RS18175 (QDV36_18180) 2811371..2812375 + 1005 WP_004199852.1 fimbrial protein -
QDV36_RS18180 (QDV36_18185) 2812508..2813800 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
QDV36_RS18185 (QDV36_18190) 2813817..2815139 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
QDV36_RS18190 (QDV36_18195) 2815139..2815405 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QDV36_RS18195 (QDV36_18200) 2815671..2815997 - 327 WP_002904788.1 hydroxyisourate hydrolase -
QDV36_RS18200 (QDV36_18205) 2815994..2816494 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
QDV36_RS18205 (QDV36_18210) 2816472..2817851 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
QDV36_RS18210 (QDV36_18215) 2818197..2819351 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
QDV36_RS18215 (QDV36_18220) 2819332..2820255 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(149-402)

Antitoxin

(16-65)


Sequences


Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T277227 WP_004199851.1 NZ_CP122587:c2815139-2813817 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp


Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT277227 WP_002904790.1 NZ_CP122587:c2815405-2815139 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References