277222

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 869423..870080 Replicon chromosome
Accession NZ_CP122587
Organism Klebsiella pneumoniae strain NCRE-61

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag QDV36_RS08580 Protein ID WP_002916310.1
Coordinates 869670..870080 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag QDV36_RS08575 Protein ID WP_002916312.1
Coordinates 869423..869689 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDV36_RS08550 (QDV36_08550) 864579..866012 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
QDV36_RS08555 (QDV36_08555) 866131..866859 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
QDV36_RS08560 (QDV36_08560) 866909..867220 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
QDV36_RS08565 (QDV36_08565) 867384..868043 + 660 WP_002916317.1 hemolysin III family protein -
QDV36_RS08570 (QDV36_08570) 868194..869177 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
QDV36_RS08575 (QDV36_08575) 869423..869689 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
QDV36_RS08580 (QDV36_08580) 869670..870080 + 411 WP_002916310.1 protein YgfX Toxin
QDV36_RS08585 (QDV36_08585) 870087..870608 - 522 WP_002916308.1 flavodoxin FldB -
QDV36_RS08590 (QDV36_08590) 870709..871605 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
QDV36_RS08595 (QDV36_08595) 871628..872341 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QDV36_RS08600 (QDV36_08600) 872347..874080 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T277222 WP_002916310.1 NZ_CP122587:869670-870080 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT277222 WP_002916312.1 NZ_CP122587:869423-869689 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References