27722

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 167401..168056 Replicon chromosome
Accession NC_017831
Organism Burkholderia pseudomallei 1026b

Toxin (Protein)


Gene name relE Uniprot ID A0A0F6LEW6
Locus tag BP1026B_RS00850 Protein ID WP_006027262.1
Coordinates 167760..168056 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q63YL3
Locus tag BP1026B_RS00845 Protein ID WP_004202809.1
Coordinates 167401..167757 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BP1026B_RS00825 162536..163549 - 1014 WP_004531048.1 phage major capsid protein, P2 family -
BP1026B_RS00830 163583..164392 - 810 WP_004552664.1 GPO family capsid scaffolding protein -
BP1026B_RS00835 164536..166305 + 1770 WP_004531046.1 terminase ATPase subunit family protein -
BP1026B_RS00840 166302..167357 + 1056 WP_004531045.1 phage portal protein -
BP1026B_RS00845 167401..167757 - 357 WP_004202809.1 putative addiction module antidote protein Antitoxin
BP1026B_RS00850 167760..168056 - 297 WP_006027262.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BP1026B_RS31560 168724..169980 + 1257 WP_004552667.1 AAA family ATPase -
BP1026B_RS00855 169983..170600 + 618 WP_031313497.1 DUF4276 family protein -
BP1026B_RS00860 171372..171698 + 327 WP_004552669.1 hypothetical protein -
BP1026B_RS00865 171691..172104 + 414 WP_004527843.1 phage tail protein I -
BP1026B_RS00870 172002..172604 + 603 WP_076880366.1 site-specific DNA-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 132784..174059 41275


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-97)

Antitoxin

Uncharacterized protein HI1420

(16-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10844.65 Da        Isoelectric Point: 10.1723

>T27722 WP_006027262.1 NC_017831:c168056-167760 [Burkholderia pseudomallei 1026b]
MFKVLTTPQFDKWLDGLRDPVGSAAINLRIERAKLGNLGQWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKLAKQIAGELED

Download         Length: 297 bp

>T27722 NC_017831:c168056-167760 [Burkholderia pseudomallei 1026b]
ATGTTCAAAGTTCTGACGACCCCCCAGTTTGACAAATGGCTTGACGGGCTTCGCGATCCGGTCGGTAGCGCGGCAATCAA
CCTGCGCATCGAGCGGGCGAAGCTTGGCAATCTCGGCCAGTGGCGCGCAGTCGGCGACGGCGTCAACGAAATGAAGATTG
ATGTGGGGCCGGGATATCGGGCCTATTTCGTGCGGCGCGGAAAAATTATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACGCAGAAGAAGGACATCAAGCTAGCGAAGCAAATCGCTGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 12585.41 Da        Isoelectric Point: 9.9470

>AT27722 WP_004202809.1 NC_017831:c167757-167401 [Burkholderia pseudomallei 1026b]
MKISELAEFDGSKYLKDEETIRHYLAQAFEDGNPRLIQAALGNVAKARGMTALARESGVKREALYRALSEGGNAEFATIM
KVVGALGLHLTVAPAEPAPVPAPATTRARSRVRTAAHA

Download         Length: 357 bp

>AT27722 NC_017831:c167757-167401 [Burkholderia pseudomallei 1026b]
ATGAAAATCAGCGAACTGGCCGAGTTCGACGGCTCGAAGTACCTGAAGGACGAGGAAACGATTCGTCACTACCTGGCGCA
AGCGTTCGAGGATGGAAACCCGCGGCTGATTCAAGCCGCGCTCGGAAACGTCGCGAAAGCGCGCGGCATGACAGCGCTCG
CGCGCGAGTCCGGCGTGAAGCGTGAAGCGCTCTATCGCGCGCTGTCGGAAGGTGGGAACGCGGAATTCGCAACGATCATG
AAAGTTGTGGGCGCGTTGGGGCTGCACCTGACCGTTGCGCCGGCCGAACCTGCGCCGGTGCCCGCGCCGGCAACAACGCG
TGCACGCTCGCGCGTTCGCACGGCTGCGCACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F6LEW6

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4G1D3

References