Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 4139..4719 Replicon plasmid pNCRE-61-15.0
Accession NZ_CP122585
Organism Klebsiella pneumoniae strain NCRE-61

Toxin (Protein)


Gene name parE Uniprot ID A0A060VNB1
Locus tag QDV36_RS04130 Protein ID WP_001136729.1
Coordinates 4139..4453 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag QDV36_RS04135 Protein ID WP_000093040.1
Coordinates 4441..4719 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDV36_RS04110 (QDV36_04105) 2547..2777 + 231 WP_231828916.1 hypothetical protein -
QDV36_RS04115 (QDV36_04110) 2784..3314 + 531 WP_065521056.1 hypothetical protein -
QDV36_RS04120 (QDV36_04115) 3342..3521 - 180 WP_065521055.1 Rop family plasmid primer RNA-binding protein -
QDV36_RS04125 (QDV36_04120) 3547..3975 - 429 WP_001140599.1 hypothetical protein -
QDV36_RS04130 (QDV36_04125) 4139..4453 - 315 WP_001136729.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QDV36_RS04135 (QDV36_04130) 4441..4719 - 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
QDV36_RS04140 (QDV36_04135) 5061..5279 - 219 WP_002193751.1 TonB family protein -
QDV36_RS04145 (QDV36_04140) 5276..5647 - 372 WP_001237044.1 cell envelope integrity protein TolA -
QDV36_RS04150 (QDV36_04145) 5921..6166 - 246 WP_004146442.1 hypothetical protein -
QDV36_RS04155 (QDV36_04150) 6493..8178 + 1686 WP_032440457.1 colicin-like bacteriocin tRNase domain-containing protein -
QDV36_RS04160 (QDV36_04155) 8188..8445 + 258 WP_032440455.1 colicin E3-like toxin immunity protein -
QDV36_RS04165 (QDV36_04160) 8530..8679 + 150 WP_032440454.1 colicin release lysis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaTEM-1B - 1..15014 15014
- flank IS/Tn - - 71..2545 2474


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11847.77 Da        Isoelectric Point: 9.8619

>T277218 WP_001136729.1 NZ_CP122585:c4453-4139 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKAGEVIVRAIQQLKTLPDIGRPVPFLPLEYQELVIGFGDSGYVMLYRHDR
EMDRIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT277218 WP_000093040.1 NZ_CP122585:c4719-4441 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VNB1

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References