Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 88315..89225 Replicon plasmid pNCRE-61-vir
Accession NZ_CP122579
Organism Klebsiella pneumoniae strain NCRE-61

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag QDV36_RS00440 Protein ID WP_004026354.1
Coordinates 88315..88785 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag QDV36_RS00445 Protein ID WP_231828928.1
Coordinates 88782..89225 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDV36_RS00420 (QDV36_00420) 83986..84480 - 495 WP_004212794.1 thermonuclease family protein -
QDV36_RS00425 (QDV36_00425) 84658..84924 + 267 WP_223175074.1 DUF1173 family protein -
QDV36_RS00430 (QDV36_00430) 84957..85607 + 651 WP_223356693.1 DUF1173 family protein -
QDV36_RS00440 (QDV36_00440) 88315..88785 - 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
QDV36_RS00445 (QDV36_00445) 88782..89225 - 444 WP_231828928.1 DUF2384 domain-containing protein Antitoxin
QDV36_RS00450 (QDV36_00450) 89326..89829 - 504 Protein_89 DUF4113 domain-containing protein -
QDV36_RS00455 (QDV36_00455) 89927..90148 - 222 WP_004213643.1 DUF2188 domain-containing protein -
QDV36_RS00460 (QDV36_00460) 90323..90448 - 126 Protein_91 Fe3+-citrate ABC transporter substrate-binding protein -
QDV36_RS00465 (QDV36_00465) 90523..92649 - 2127 WP_004213640.1 TonB-dependent Fe(3+) dicitrate receptor FecA -
QDV36_RS00470 (QDV36_00470) 92736..93689 - 954 Protein_93 fec operon regulator FecR -
QDV36_RS00475 (QDV36_00475) 93686..94207 - 522 WP_004213635.1 ferric citrate uptake sigma factor FecI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - iroB / iroC / iroD / iroN / rmpA / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA / pla 1..205089 205089


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre

(16-147)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T277214 WP_004026354.1 NZ_CP122579:c88785-88315 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16470.76 Da        Isoelectric Point: 10.2498

>AT277214 WP_231828928.1 NZ_CP122579:c89225-88782 [Klebsiella pneumoniae]
MKTFSLSSTPARSQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure

References