Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5206600..5207225 Replicon chromosome
Accession NZ_CP122578
Organism Klebsiella pneumoniae strain KP-2683-1

Toxin (Protein)


Gene name vapC Uniprot ID A0A330XB05
Locus tag QDV38_RS27925 Protein ID WP_012737091.1
Coordinates 5206600..5206983 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag QDV38_RS27930 Protein ID WP_004150355.1
Coordinates 5206983..5207225 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDV38_RS27910 (5203966) 5203966..5204868 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
QDV38_RS27915 (5204865) 5204865..5205500 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
QDV38_RS27920 (5205497) 5205497..5206426 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
QDV38_RS27925 (5206600) 5206600..5206983 - 384 WP_012737091.1 type II toxin-antitoxin system VapC family toxin Toxin
QDV38_RS27930 (5206983) 5206983..5207225 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
QDV38_RS27935 (5207430) 5207430..5208347 + 918 WP_012737090.1 alpha/beta hydrolase -
QDV38_RS27940 (5208361) 5208361..5209302 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
QDV38_RS27945 (5209347) 5209347..5209784 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
QDV38_RS27950 (5209781) 5209781..5210641 - 861 WP_004146232.1 virulence factor BrkB family protein -
QDV38_RS27955 (5210635) 5210635..5211234 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-110)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14266.53 Da        Isoelectric Point: 7.2771

>T277212 WP_012737091.1 NZ_CP122578:c5206983-5206600 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRCEAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKGFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT277212 WP_004150355.1 NZ_CP122578:c5207225-5206983 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A330XB05

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References