Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4735575..4736091 Replicon chromosome
Accession NZ_CP122578
Organism Klebsiella pneumoniae strain KP-2683-1

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag QDV38_RS25675 Protein ID WP_004178374.1
Coordinates 4735575..4735859 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag QDV38_RS25680 Protein ID WP_002886901.1
Coordinates 4735849..4736091 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDV38_RS25650 (4730971) 4730971..4731234 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
QDV38_RS25655 (4731364) 4731364..4731537 + 174 WP_041169004.1 hypothetical protein -
QDV38_RS25660 (4731540) 4731540..4732283 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
QDV38_RS25665 (4732640) 4732640..4734778 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
QDV38_RS25670 (4735107) 4735107..4735571 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
QDV38_RS25675 (4735575) 4735575..4735859 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QDV38_RS25680 (4735849) 4735849..4736091 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QDV38_RS25685 (4736169) 4736169..4738079 - 1911 WP_012737231.1 PRD domain-containing protein -
QDV38_RS25690 (4738102) 4738102..4739256 - 1155 WP_012737230.1 lactonase family protein -
QDV38_RS25695 (4739323) 4739323..4740063 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T277211 WP_004178374.1 NZ_CP122578:c4735859-4735575 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT277211 WP_002886901.1 NZ_CP122578:c4736091-4735849 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References