Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4569664..4570474 Replicon chromosome
Accession NZ_CP122578
Organism Klebsiella pneumoniae strain KP-2683-1

Toxin (Protein)


Gene name KacT Uniprot ID A0A332NV98
Locus tag QDV38_RS24950 Protein ID WP_014908042.1
Coordinates 4569664..4570197 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag QDV38_RS24955 Protein ID WP_002887278.1
Coordinates 4570208..4570474 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDV38_RS24945 (4568495) 4568495..4569616 + 1122 WP_012737335.1 cupin domain-containing protein -
QDV38_RS24950 (4569664) 4569664..4570197 - 534 WP_014908042.1 type II toxin-antitoxin system toxin KacT Toxin
QDV38_RS24955 (4570208) 4570208..4570474 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
QDV38_RS24960 (4570577) 4570577..4572010 - 1434 WP_014908043.1 Cu(+)/Ag(+) sensor histidine kinase -
QDV38_RS24965 (4572000) 4572000..4572683 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
QDV38_RS24970 (4572855) 4572855..4574240 + 1386 WP_012737332.1 efflux transporter outer membrane subunit -
QDV38_RS24975 (4574258) 4574258..4574602 + 345 WP_012737331.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-150)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19795.68 Da        Isoelectric Point: 5.2614

>T277210 WP_014908042.1 NZ_CP122578:c4570197-4569664 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGLGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT277210 WP_002887278.1 NZ_CP122578:c4570474-4570208 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A332NV98

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References