Detailed information of TA system TA027721

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 30423..31066
• Replicon: plasmid P5
• Accession: NC_017806
• Organism: Deinococcus gobiensis I-0

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: DGO_RS20560
• Protein ID: WP_043805246.1
• Coordinates: 30656..31066 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: H8H3T3
• Locus tag: DGO_RS20555
• Protein ID: WP_014695822.1
• Coordinates: 30423..30659 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DGO_RS20540	26470..27237	+	768	WP_014695817.1	ParA family protein	-
DGO_RS20545	27234..28142	+	909	WP_014695818.1	ParB/RepB/Spo0J family partition protein	-
DGO_RS22790	28347..28589	+	243	WP_014695819.1	hypothetical protein	-
DGO_RS23655	28663..29067	+	405	WP_169331074.1	cupredoxin domain-containing protein	-
DGO_RS20550	29245..30258	-	1014	WP_014695821.1	hypothetical protein	-
DGO_RS20555	30423..30659	+	237	WP_014695822.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
DGO_RS20560	30656..31066	+	411	WP_043805246.1	type II toxin-antitoxin system VapC family toxin	Toxin
DGO_RS23995	32240..32746	-	507	WP_169331075.1	hypothetical protein	-
DGO_RS24000	32743..33106	-	364	Protein_22	DUF1064 domain-containing protein	-
DGO_RS20575	34082..34522	-	441	WP_043805250.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..54602	54602

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-126)

Antitoxin

• SpoVT-AbrB domain (7-42)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15043.36 Da
• Isoelectric Point: 5.1295

>T27721 WP_043805246.1 NC_017806:30656-31066 [Deinococcus gobiensis I-0]
MSLRYLLDTNICIFIIKNRPAAVRARFQVLKPGELGISAITEAELLHGAYKSQRVEQNLAAVLDFSAQMEIVPFDSQITD
TYGQLRAGLEQQGTPIGPLDFQIAATALACGLPLVTNNTREFRRVPGLLLEDWTQV

Nucleotide

• Length: 411 bp

>T27721 NC_017806:30656-31066 [Deinococcus gobiensis I-0]
CTGAGCCTACGCTATCTCCTCGACACGAACATCTGCATCTTCATCATCAAGAACCGCCCAGCAGCCGTGAGGGCCCGCTT
TCAGGTCCTCAAGCCTGGGGAGCTGGGGATCAGCGCCATTACCGAGGCGGAGTTGCTGCACGGAGCGTACAAGAGTCAGC
GGGTCGAGCAAAACCTCGCGGCCGTACTGGACTTCTCAGCGCAGATGGAGATCGTACCCTTCGACTCGCAGATCACGGAT
ACCTATGGGCAGCTGCGCGCGGGGCTCGAACAGCAGGGCACCCCGATCGGCCCACTGGATTTTCAGATCGCCGCGACTGC
ACTGGCATGTGGTTTACCGCTGGTCACGAACAACACCCGGGAGTTCAGGCGGGTTCCCGGTCTCCTGCTGGAAGACTGGA
CCCAGGTCTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8582.74 Da
• Isoelectric Point: 4.7063

>AT27721 WP_014695822.1 NC_017806:30423-30659 [Deinococcus gobiensis I-0]
MVTVKVFQSGNSQAVRLPRELRLEVSELQVTRRGDVLILRPVALGTSLVGAFDALAQVGDDFLPEGRQQGSEQEREAF

Nucleotide

• Length: 237 bp

>AT27721 NC_017806:30423-30659 [Deinococcus gobiensis I-0]
ATGGTCACTGTCAAGGTCTTCCAGAGTGGCAATTCACAAGCGGTCCGGCTTCCCAGGGAACTGCGGTTGGAGGTCAGCGA
ATTACAGGTCACCCGCCGGGGGGACGTTCTGATCCTGCGTCCCGTCGCTCTGGGGACGAGTCTCGTGGGCGCCTTCGACG
CGCTGGCTCAGGTCGGGGACGACTTCCTGCCCGAGGGGCGCCAGCAGGGCAGCGAGCAGGAGCGTGAAGCGTTCTGA

Structures

Antitoxin

• AlphaFold DB: H8H3T3