Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2620394..2621982 Replicon chromosome
Accession NZ_CP122578
Organism Klebsiella pneumoniae strain KP-2683-1

Toxin (Protein)


Gene name hipA Uniprot ID A0A331XLA5
Locus tag QDV38_RS15625 Protein ID WP_014907613.1
Coordinates 2620394..2621716 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag QDV38_RS15630 Protein ID WP_002904790.1
Coordinates 2621716..2621982 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDV38_RS15610 (2615450) 2615450..2617951 + 2502 WP_014907611.1 fimbria/pilus outer membrane usher protein -
QDV38_RS15615 (2617939) 2617939..2618943 + 1005 WP_014907612.1 fimbrial protein -
QDV38_RS15620 (2619085) 2619085..2620377 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
QDV38_RS15625 (2620394) 2620394..2621716 - 1323 WP_014907613.1 type II toxin-antitoxin system HipA family toxin Toxin
QDV38_RS15630 (2621716) 2621716..2621982 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QDV38_RS15635 (2622220) 2622220..2622546 - 327 WP_004215084.1 hydroxyisourate hydrolase -
QDV38_RS15640 (2622543) 2622543..2623043 - 501 WP_004184022.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
QDV38_RS15645 (2623021) 2623021..2624400 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
QDV38_RS15650 (2624746) 2624746..2625900 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
QDV38_RS15655 (2625881) 2625881..2626804 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49139.47 Da        Isoelectric Point: 7.5367

>T277208 WP_014907613.1 NZ_CP122578:c2621716-2620394 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT277208 WP_002904790.1 NZ_CP122578:c2621982-2621716 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A331XLA5

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References