Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 798477..799134 Replicon chromosome
Accession NZ_CP122578
Organism Klebsiella pneumoniae strain KP-2683-1

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag QDV38_RS06840 Protein ID WP_002916310.1
Coordinates 798724..799134 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag QDV38_RS06835 Protein ID WP_002916312.1
Coordinates 798477..798743 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDV38_RS06810 (793685) 793685..795118 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
QDV38_RS06815 (795237) 795237..795965 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
QDV38_RS06820 (796015) 796015..796326 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
QDV38_RS06825 (796490) 796490..797149 + 660 WP_002916317.1 hemolysin III family protein -
QDV38_RS06830 (797248) 797248..798231 - 984 WP_014906951.1 tRNA-modifying protein YgfZ -
QDV38_RS06835 (798477) 798477..798743 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
QDV38_RS06840 (798724) 798724..799134 + 411 WP_002916310.1 protein YgfX Toxin
QDV38_RS06845 (799141) 799141..799662 - 522 WP_002916308.1 flavodoxin FldB -
QDV38_RS06850 (799763) 799763..800659 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
QDV38_RS06855 (800682) 800682..801395 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QDV38_RS06860 (801401) 801401..803134 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T277202 WP_002916310.1 NZ_CP122578:798724-799134 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT277202 WP_002916312.1 NZ_CP122578:798477-798743 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References