Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 1528730..1529244 Replicon chromosome
Accession NC_017803
Organism Actinoplanes sp. SE50/110

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag ACPL_RS06820 Protein ID WP_014688436.1
Coordinates 1528730..1528990 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID G8S4Y5
Locus tag ACPL_RS06825 Protein ID WP_014688437.1
Coordinates 1528987..1529244 (-) Length 86 a.a.

Genomic Context

ACPL_RS06805ACPL_RS06810ACPL_RS41285ACPL_RS06835ACPL_RS06845ACPL_RS06820ACPL_RS06825ACPL_RS06830ACPL_RS44560ACPL_RS06840
Location: 1524257..1526347 (2091 bp)
Type: Others
Protein ID: WP_080127737.1
Location: 1526785..1527912 (1128 bp)
Type: Others
Protein ID: WP_197688122.1
Location: 1527970..1528707 (738 bp)
Type: Others
Protein ID: WP_014688435.1
Location: 1531624..1531875 (252 bp)
Type: Others
Protein ID: WP_155123448.1
Location: 1532744..1533106 (363 bp)
Type: Others
Protein ID: WP_014688443.1
Location: 1528730..1528990 (261 bp)
Type: Toxin
Protein ID: WP_014688436.1
Location: 1528987..1529244 (258 bp)
Type: Antitoxin
Protein ID: WP_014688437.1
Location: 1530703..1531104 (402 bp)
Type: Others
Protein ID: WP_043510958.1
Location: 1531214..1531435 (222 bp)
Type: Others
Protein ID: WP_155123447.1
Location: 1531975..1532685 (711 bp)
Type: Others
Protein ID: WP_014688442.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ACPL_RS068051524257..1526347+2091WP_080127737.1UvrD-helicase domain-containing protein-
ACPL_RS068101526785..1527912+1128WP_197688122.1hypothetical protein-
ACPL_RS412851527970..1528707+738WP_014688435.1hypothetical protein-
ACPL_RS068201528730..1528990-261WP_014688436.1Txe/YoeB family addiction module toxinToxin
ACPL_RS068251528987..1529244-258WP_014688437.1type II toxin-antitoxin system prevent-host-death family antitoxinAntitoxin
ACPL_RS068301530703..1531104-402WP_043510958.1hypothetical protein-
ACPL_RS445601531214..1531435-222WP_155123447.1hypothetical protein-
ACPL_RS068351531624..1531875+252WP_155123448.1hypothetical protein-
ACPL_RS068401531975..1532685-711WP_014688442.1SDR family oxidoreductase-
ACPL_RS068451532744..1533106+363WP_014688443.1MerR family transcriptional regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(4-70)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10231.53 Da        Isoelectric Point: 8.0720

>T27720 WP_014688436.1 NC_017803:c1528990-1528730 [Actinoplanes sp. SE50/110]
VKLSWTDHAWDDYLYRQTQDRRTLKRINALIADIKRDPDGQGIGKPEILRNNLAGLRSRRIDDEHRMVYAVETNEITIIS
CRYHHE

Download         Length: 261 bp

>T27720 NC_017803:c1528990-1528730 [Actinoplanes sp. SE50/110]
GTGAAACTCAGCTGGACCGACCACGCCTGGGACGACTACCTGTACCGGCAGACTCAGGACCGCAGAACCCTCAAACGCAT
CAACGCCCTGATCGCCGACATCAAACGTGATCCCGACGGTCAGGGCATCGGCAAACCGGAGATCCTCCGAAACAACCTCG
CGGGACTCCGGTCCCGGCGCATCGACGACGAACACCGCATGGTGTACGCCGTCGAGACCAACGAGATCACCATCATCTCC
TGCCGATACCATCACGAATAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9598.77 Da        Isoelectric Point: 5.1667

>AT27720 WP_014688437.1 NC_017803:c1529244-1528987 [Actinoplanes sp. SE50/110]
VTSAISASEARKSLFPLIERVNLDHTPIEIVSKRGNAVLVSKEDWDSIMETNYLLRSPANAKRLTESVEQWRAGRATERE
FGPEE

Download         Length: 258 bp

>AT27720 NC_017803:c1529244-1528987 [Actinoplanes sp. SE50/110]
GTGACTTCAGCGATCAGTGCCAGCGAGGCTCGCAAGTCCCTCTTTCCGCTCATCGAACGAGTCAACCTGGACCACACTCC
GATCGAAATCGTCTCCAAGCGCGGCAACGCCGTCCTGGTGAGCAAGGAGGACTGGGACTCGATCATGGAAACCAACTACC
TGCTTCGATCCCCCGCCAACGCCAAGCGCCTCACTGAGAGCGTCGAGCAATGGCGAGCGGGACGAGCCACGGAGCGCGAG
TTCGGCCCCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBG8S4Y5

References