Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 158246..158823 Replicon plasmid pKP-2683-1-174.8
Accession NZ_CP122576
Organism Klebsiella pneumoniae strain KP-2683-1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag QDV38_RS02680 Protein ID WP_023286013.1
Coordinates 158491..158823 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag QDV38_RS02675 Protein ID WP_023286014.1
Coordinates 158246..158491 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDV38_RS02645 (QDV38_02650) 153905..154342 + 438 WP_080861790.1 plasmid protein -
QDV38_RS02650 (QDV38_02655) 154339..155025 + 687 WP_253900371.1 hypothetical protein -
QDV38_RS02655 (QDV38_02660) 155066..155674 + 609 WP_253900372.1 hypothetical protein -
QDV38_RS02660 (QDV38_02665) 156508..157194 + 687 WP_150150043.1 hypothetical protein -
QDV38_RS02665 (QDV38_02670) 157262..157537 + 276 WP_080861794.1 hypothetical protein -
QDV38_RS02670 (QDV38_02675) 157607..158164 + 558 WP_141489877.1 hypothetical protein -
QDV38_RS02675 (QDV38_02680) 158246..158491 + 246 WP_023286014.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
QDV38_RS02680 (QDV38_02685) 158491..158823 + 333 WP_023286013.1 endoribonuclease MazF Toxin
QDV38_RS02685 (QDV38_02690) 159103..159417 + 315 WP_114261650.1 hypothetical protein -
QDV38_RS02690 (QDV38_02695) 159542..160180 + 639 WP_279956646.1 hypothetical protein -
QDV38_RS02695 (QDV38_02700) 160192..160494 + 303 WP_023286010.1 hypothetical protein -
QDV38_RS02700 (QDV38_02705) 160586..161005 + 420 WP_023286009.1 hypothetical protein -
QDV38_RS02705 (QDV38_02710) 161054..161368 + 315 WP_023286008.1 hypothetical protein -
QDV38_RS02710 (QDV38_02715) 161358..161564 + 207 WP_023286007.1 hypothetical protein -
QDV38_RS02715 (QDV38_02720) 161734..162594 + 861 WP_023286006.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..174840 174840


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-107)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11943.82 Da        Isoelectric Point: 8.7208

>T277199 WP_023286013.1 NZ_CP122576:158491-158823 [Klebsiella pneumoniae]
MVKRYVPDAGDLIWIDFDPVAGHEQGGHRPAVVLSPFAYNNKVGLLLCVPCTTQVKGYPFEVTLSGSKEGVALSDQITCV
DWRARKVTQKSTVSKSELAEIRAKAKALIG

Download         Length: 333 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8742.11 Da        Isoelectric Point: 5.0176

>AT277199 WP_023286014.1 NZ_CP122576:158246-158491 [Klebsiella pneumoniae]
MAQVIVKKWGNSPSVRLPVAVMKAASLNVDDTVDIEVEDGRIIIVPARPKEYSLDALLSGISSDNLHDKVDFGPAKGKEL
L

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References