Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 103383..104293 Replicon plasmid pKP-2683-1-vir
Accession NZ_CP122574
Organism Klebsiella pneumoniae strain KP-2683-1

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag QDV38_RS00565 Protein ID WP_004026354.1
Coordinates 103383..103853 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6P1V3Q9
Locus tag QDV38_RS00570 Protein ID WP_004026357.1
Coordinates 103850..104293 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDV38_RS00540 (QDV38_00540) 98795..99193 - 399 WP_004212796.1 H-NS family nucleoid-associated regulatory protein -
QDV38_RS00545 (QDV38_00545) 99530..100024 - 495 WP_004212794.1 thermonuclease family protein -
QDV38_RS00550 (QDV38_00550) 100202..100468 + 267 WP_223175074.1 DUF1173 family protein -
QDV38_RS00555 (QDV38_00555) 100459..101151 + 693 WP_011154578.1 DUF1173 family protein -
QDV38_RS00565 (QDV38_00565) 103383..103853 - 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
QDV38_RS00570 (QDV38_00570) 103850..104293 - 444 WP_004026357.1 DUF2384 domain-containing protein Antitoxin
QDV38_RS00575 (QDV38_00575) 104394..104897 - 504 Protein_114 DUF4113 domain-containing protein -
QDV38_RS00580 (QDV38_00580) 104995..105216 - 222 WP_004213643.1 DUF2188 domain-containing protein -
QDV38_RS00585 (QDV38_00585) 105391..105516 - 126 Protein_116 Fe3+-citrate ABC transporter substrate-binding protein -
QDV38_RS00590 (QDV38_00590) 105591..107717 - 2127 WP_004213640.1 TonB-dependent Fe(3+) dicitrate receptor FecA -
QDV38_RS00595 (QDV38_00595) 107804..108757 - 954 Protein_118 fec operon regulator FecR -
QDV38_RS00600 (QDV38_00600) 108754..109275 - 522 WP_004213635.1 ferric citrate uptake sigma factor FecI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - iroB / iroC / iroD / iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA 1..229269 229269
- flank IS/Tn - - 102537..103040 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T277197 WP_004026354.1 NZ_CP122574:c103853-103383 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16480.80 Da        Isoelectric Point: 10.2498

>AT277197 WP_004026357.1 NZ_CP122574:c104293-103850 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V3Q9

References