277195

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5210034..5210659 Replicon chromosome
Accession NZ_CP122573
Organism Klebsiella pneumoniae strain KP2185

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag QDV37_RS29695 Protein ID WP_002882817.1
Coordinates 5210034..5210417 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag QDV37_RS29700 Protein ID WP_004150355.1
Coordinates 5210417..5210659 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDV37_RS29680 (QDV37_29700) 5207400..5208302 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
QDV37_RS29685 (QDV37_29705) 5208299..5208934 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
QDV37_RS29690 (QDV37_29710) 5208931..5209860 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
QDV37_RS29695 (QDV37_29715) 5210034..5210417 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
QDV37_RS29700 (QDV37_29720) 5210417..5210659 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
QDV37_RS29705 (QDV37_29725) 5210864..5211781 + 918 WP_108714542.1 alpha/beta hydrolase -
QDV37_RS29710 (QDV37_29730) 5211795..5212736 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
QDV37_RS29715 (QDV37_29735) 5212781..5213218 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
QDV37_RS29720 (QDV37_29740) 5213215..5214075 - 861 WP_002882807.1 virulence factor BrkB family protein -
QDV37_RS29725 (QDV37_29745) 5214069..5214668 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T277195 WP_002882817.1 NZ_CP122573:c5210417-5210034 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT277195 WP_004150355.1 NZ_CP122573:c5210659-5210417 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References