Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4729800..4730316 Replicon chromosome
Accession NZ_CP122573
Organism Klebsiella pneumoniae strain KP2185

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag QDV37_RS27390 Protein ID WP_002886902.1
Coordinates 4729800..4730084 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag QDV37_RS27395 Protein ID WP_002886901.1
Coordinates 4730074..4730316 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDV37_RS27365 (QDV37_27385) 4725284..4725547 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
QDV37_RS27370 (QDV37_27390) 4725677..4725850 + 174 WP_002886906.1 hypothetical protein -
QDV37_RS27375 (QDV37_27395) 4725853..4726596 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
QDV37_RS27380 (QDV37_27400) 4726953..4729091 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
QDV37_RS27385 (QDV37_27405) 4729332..4729796 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
QDV37_RS27390 (QDV37_27410) 4729800..4730084 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QDV37_RS27395 (QDV37_27415) 4730074..4730316 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QDV37_RS27400 (QDV37_27420) 4730394..4732304 - 1911 WP_004152270.1 PRD domain-containing protein -
QDV37_RS27405 (QDV37_27425) 4732327..4733481 - 1155 WP_002886900.1 lactonase family protein -
QDV37_RS27410 (QDV37_27430) 4733547..4734287 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T277193 WP_002886902.1 NZ_CP122573:c4730084-4729800 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT277193 WP_002886901.1 NZ_CP122573:c4730316-4730074 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References