Detailed information of TA system TA027719

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 62203..62858
• Replicon: plasmid P4
• Accession: NC_017792
• Organism: Deinococcus gobiensis I-0

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: H8H3P0
• Locus tag: DGO_RS20440
• Protein ID: WP_014686947.1
• Coordinates: 62442..62858 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: H8H3N9
• Locus tag: DGO_RS20435
• Protein ID: WP_014686946.1
• Coordinates: 62203..62442 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DGO_RS20420	57222..59909	+	2688	WP_014686943.1	class III lanthionine synthetase LanKC	-
DGO_RS20425	59906..61555	+	1650	WP_014686944.1	ABC transporter ATP-binding protein/permease	-
DGO_RS20430	61940..62128	+	189	WP_145975596.1	hypothetical protein	-
DGO_RS20435	62203..62442	+	240	WP_014686946.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
DGO_RS20440	62442..62858	+	417	WP_014686947.1	type II toxin-antitoxin system VapC family toxin	Toxin
DGO_RS21485	63435..64025	+	591	WP_145975597.1	hypothetical protein	-
DGO_RS20450	64277..64609	+	333	WP_014686949.1	helix-turn-helix transcriptional regulator	-
DGO_RS20455	64606..65757	+	1152	WP_014686950.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..72036	72036

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-126)

Antitoxin

• SpoVT-AbrB domain (7-39)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15114.43 Da
• Isoelectric Point: 6.8711

>T27719 WP_014686947.1 NC_017792:62442-62858 [Deinococcus gobiensis I-0]
MSVTHLLDTNTCIYIINRRPPGVAEKFAQFSPDAIGLSSITLAELHFGVAKSGSTKNLKALEAFLEPLEVLPFSAAASVL
YGRIRTELERQGQPIGAMDLLIAAHALTLGVTLVTHNRREFDRVAGLQIDNWFSPEVR

Nucleotide

• Length: 417 bp

>T27719 NC_017792:62442-62858 [Deinococcus gobiensis I-0]
ATGTCCGTCACCCACCTCCTCGACACGAACACCTGCATCTACATCATCAACCGTCGTCCCCCAGGCGTCGCTGAAAAGTT
CGCGCAGTTTTCACCGGACGCCATCGGTCTGTCGAGCATCACCCTTGCCGAACTGCATTTTGGCGTAGCCAAGAGCGGCT
CGACCAAGAACCTCAAGGCGCTGGAGGCTTTCCTTGAACCTCTGGAAGTGCTGCCCTTCAGTGCGGCCGCCAGCGTCCTG
TATGGCCGCATCCGCACCGAGTTGGAGCGGCAGGGCCAGCCGATCGGCGCGATGGATCTCCTGATTGCTGCTCATGCCCT
GACCCTGGGCGTCACCCTCGTGACCCACAACCGCAGGGAGTTTGACCGGGTGGCTGGCCTCCAGATCGACAACTGGTTCA
GTCCGGAAGTTCGCTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9070.43 Da
• Isoelectric Point: 4.9816

>AT27719 WP_014686946.1 NC_017792:62203-62442 [Deinococcus gobiensis I-0]
MTTAKLFLTGRSQAVRLPKAFRFEGQEVIIKRVSNGVLLLPQDPEGQLAFWQGWYTAIPETDVPLTREDLPLQDRDWTL

Nucleotide

• Length: 240 bp

>AT27719 NC_017792:62203-62442 [Deinococcus gobiensis I-0]
ATGACCACTGCCAAGCTCTTCCTCACCGGCCGCTCCCAGGCTGTCCGCCTCCCCAAAGCCTTCCGCTTCGAAGGCCAGGA
AGTCATCATCAAGCGGGTCTCCAATGGCGTCCTCCTTCTTCCCCAGGACCCGGAAGGTCAACTCGCCTTCTGGCAGGGCT
GGTACACCGCCATTCCCGAGACCGACGTCCCGCTGACCCGCGAGGACCTTCCCCTCCAGGACCGTGACTGGACGTTGTAA

Structures

Toxin

• AlphaFold DB: H8H3P0

Antitoxin

• AlphaFold DB: H8H3N9