Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 2316..2896 Replicon plasmid pKP2185-15.0
Accession NZ_CP122572
Organism Klebsiella pneumoniae strain KP2185

Toxin (Protein)


Gene name parE Uniprot ID A0A060VNB1
Locus tag QDV37_RS03760 Protein ID WP_001136729.1
Coordinates 2316..2630 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag QDV37_RS03765 Protein ID WP_000093040.1
Coordinates 2618..2896 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDV37_RS03740 (QDV37_03740) 724..954 + 231 WP_231828916.1 hypothetical protein -
QDV37_RS03745 (QDV37_03745) 961..1491 + 531 WP_065521056.1 hypothetical protein -
QDV37_RS03750 (QDV37_03750) 1519..1698 - 180 WP_065521055.1 Rop family plasmid primer RNA-binding protein -
QDV37_RS03755 (QDV37_03755) 1724..2152 - 429 WP_001140599.1 hypothetical protein -
QDV37_RS03760 (QDV37_03760) 2316..2630 - 315 WP_001136729.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QDV37_RS03765 (QDV37_03765) 2618..2896 - 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
QDV37_RS03770 (QDV37_03770) 3238..3456 - 219 WP_002193751.1 TonB family protein -
QDV37_RS03775 (QDV37_03775) 3453..3824 - 372 WP_001237044.1 cell envelope integrity protein TolA -
QDV37_RS03780 (QDV37_03780) 4098..4343 - 246 WP_004146442.1 hypothetical protein -
QDV37_RS03785 (QDV37_03785) 4670..6355 + 1686 WP_032440457.1 colicin-like bacteriocin tRNase domain-containing protein -
QDV37_RS03790 (QDV37_03790) 6365..6622 + 258 WP_032440455.1 colicin E3-like toxin immunity protein -
QDV37_RS03795 (QDV37_03795) 6707..6856 + 150 WP_032440454.1 colicin release lysis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaTEM-1B - 1..15032 15032
- flank IS/Tn - - 102..722 620


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11847.77 Da        Isoelectric Point: 9.8619

>T277181 WP_001136729.1 NZ_CP122572:c2630-2316 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKAGEVIVRAIQQLKTLPDIGRPVPFLPLEYQELVIGFGDSGYVMLYRHDR
EMDRIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT277181 WP_000093040.1 NZ_CP122572:c2896-2618 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VNB1

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References