Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 86988..87898 Replicon plasmid pKP2185-vir
Accession NZ_CP122567
Organism Klebsiella pneumoniae strain KP2185

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag QDV37_RS00435 Protein ID WP_004026354.1
Coordinates 86988..87458 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag QDV37_RS00440 Protein ID WP_231828928.1
Coordinates 87455..87898 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDV37_RS00415 (QDV37_00415) 82659..83153 - 495 WP_004212794.1 thermonuclease family protein -
QDV37_RS00420 (QDV37_00420) 83331..83597 + 267 WP_223175074.1 DUF1173 family protein -
QDV37_RS00425 (QDV37_00425) 83630..84280 + 651 WP_223356693.1 DUF1173 family protein -
QDV37_RS00435 (QDV37_00435) 86988..87458 - 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
QDV37_RS00440 (QDV37_00440) 87455..87898 - 444 WP_231828928.1 DUF2384 domain-containing protein Antitoxin
QDV37_RS00445 (QDV37_00445) 87999..88502 - 504 Protein_88 DUF4113 domain-containing protein -
QDV37_RS00450 (QDV37_00450) 88600..88821 - 222 WP_004213643.1 DUF2188 domain-containing protein -
QDV37_RS00455 (QDV37_00455) 88996..89121 - 126 Protein_90 Fe3+-citrate ABC transporter substrate-binding protein -
QDV37_RS00460 (QDV37_00460) 89196..91322 - 2127 WP_004213640.1 TonB-dependent Fe(3+) dicitrate receptor FecA -
QDV37_RS00465 (QDV37_00465) 91409..92362 - 954 Protein_92 fec operon regulator FecR -
QDV37_RS00470 (QDV37_00470) 92359..92880 - 522 WP_004213635.1 ferric citrate uptake sigma factor FecI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - iroB / iroC / iroD / iroN / rmpA / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA / pla 1..203769 203769
- flank IS/Tn - - 85666..86169 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre

(16-147)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T277177 WP_004026354.1 NZ_CP122567:c87458-86988 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16470.76 Da        Isoelectric Point: 10.2498

>AT277177 WP_231828928.1 NZ_CP122567:c87898-87455 [Klebsiella pneumoniae]
MKTFSLSSTPARSQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure

References