Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4782839..4783475 Replicon chromosome
Accession NZ_CP122540
Organism Pseudomonas brenneri strain K5-sn1400

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QDY63_RS22015 Protein ID WP_032862617.1
Coordinates 4782839..4783243 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A5B2UU56
Locus tag QDY63_RS22020 Protein ID WP_032862615.1
Coordinates 4783236..4783475 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QDY63_RS21995 (QDY63_21995) 4778890..4780173 + 1284 WP_032861590.1 ABC transporter substrate-binding protein -
QDY63_RS22000 (QDY63_22000) 4780653..4781903 + 1251 WP_090291778.1 ribonucleotide-diphosphate reductase subunit beta -
QDY63_RS22005 (QDY63_22005) 4781979..4782146 + 168 Protein_4327 HNH endonuclease -
QDY63_RS22010 (QDY63_22010) 4782174..4782818 + 645 WP_032862618.1 HAD-IB family hydrolase -
QDY63_RS22015 (QDY63_22015) 4782839..4783243 - 405 WP_032862617.1 type II toxin-antitoxin system VapC family toxin Toxin
QDY63_RS22020 (QDY63_22020) 4783236..4783475 - 240 WP_032862615.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QDY63_RS22025 (QDY63_22025) 4783678..4784628 + 951 WP_032862614.1 hypothetical protein -
QDY63_RS22030 (QDY63_22030) 4784753..4785127 + 375 WP_032862613.1 helix-turn-helix transcriptional regulator -
QDY63_RS22035 (QDY63_22035) 4785147..4785812 - 666 WP_156356823.1 hypothetical protein -
QDY63_RS22040 (QDY63_22040) 4786052..4787107 - 1056 WP_032862612.1 MBL fold metallo-hydrolase -
QDY63_RS22045 (QDY63_22045) 4787242..4787865 + 624 WP_032862611.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-54)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15167.45 Da        Isoelectric Point: 7.4666

>T277168 WP_032862617.1 NZ_CP122540:c4783243-4782839 [Pseudomonas brenneri]
MIKYMLDTNIVIYIIKRRPIEILEKFNANVGRLVISSITLAELMHGAEKSQFVERNTRAVEDFTSRLDIIHYDEKAAFHY
GSIRSDLEKKGTPIGVNDLHIASHARSSGLVLVTNNEGEFKRVNGLLVENWIAA

Download         Length: 405 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8938.83 Da        Isoelectric Point: 4.0941

>AT277168 WP_032862615.1 NZ_CP122540:c4783475-4783236 [Pseudomonas brenneri]
MSTGTVFTNNRTQNIRIPAELRFPDGVKTVEVRAVGRDLIISPVENTWDSFFLAGESVSDDFMAERTEPAQQERESFDD

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5B2UU56

References