Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4261311..4261808 Replicon chromosome
Accession NZ_CP122517
Organism Escherichia coli strain MY1-8

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QCL60_RS20605 Protein ID WP_001173343.1
Coordinates 4261311..4261484 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag QCL60_RS20610 Protein ID WP_000398619.1
Coordinates 4261512..4261808 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCL60_RS20595 (4257981) 4257981..4259438 + 1458 WP_032266231.1 dipeptide/tripeptide permease DtpC -
QCL60_RS20600 (4259675) 4259675..4261192 + 1518 WP_001295074.1 lysine--tRNA ligase -
QCL60_RS20605 (4261311) 4261311..4261484 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QCL60_RS20610 (4261512) 4261512..4261808 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QCL60_RS20615 (4262035) 4262035..4262307 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
QCL60_RS20620 (4262319) 4262319..4262549 - 231 WP_000371698.1 4Fe-4S mono-cluster protein YjdI -
QCL60_RS20625 (4262730) 4262730..4264361 + 1632 WP_001216461.1 sensor histidine kinase -
QCL60_RS20630 (4264358) 4264358..4265077 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T277153 WP_001173343.1 NZ_CP122517:c4261484-4261311 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT277153 WP_000398619.1 NZ_CP122517:c4261808-4261512 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References