Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4158804..4159399 Replicon chromosome
Accession NZ_CP122517
Organism Escherichia coli strain MY1-8

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag QCL60_RS20090 Protein ID WP_000239579.1
Coordinates 4158804..4159154 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag QCL60_RS20095 Protein ID WP_001223208.1
Coordinates 4159148..4159399 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCL60_RS20070 (4154080) 4154080..4155102 - 1023 WP_001517822.1 ABC transporter permease -
QCL60_RS20075 (4155116) 4155116..4156618 - 1503 WP_000205793.1 sugar ABC transporter ATP-binding protein -
QCL60_RS20080 (4156928) 4156928..4157884 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
QCL60_RS20085 (4158194) 4158194..4158724 + 531 WP_000055072.1 inorganic diphosphatase -
QCL60_RS20090 (4158804) 4158804..4159154 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
QCL60_RS20095 (4159148) 4159148..4159399 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
QCL60_RS20100 (4159612) 4159612..4159953 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
QCL60_RS20105 (4159956) 4159956..4163735 - 3780 WP_000060901.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T277152 WP_000239579.1 NZ_CP122517:c4159154-4158804 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT277152 WP_001223208.1 NZ_CP122517:c4159399-4159148 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References