Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 3521098..3521935 Replicon chromosome
Accession NZ_CP122517
Organism Escherichia coli strain MY1-8

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag QCL60_RS17125 Protein ID WP_000227784.1
Coordinates 3521393..3521935 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag QCL60_RS17120 Protein ID WP_001297137.1
Coordinates 3521098..3521409 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCL60_RS17095 (3516118) 3516118..3517065 + 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -
QCL60_RS17100 (3517087) 3517087..3519078 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
QCL60_RS17105 (3519068) 3519068..3519682 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
QCL60_RS17110 (3519682) 3519682..3520011 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
QCL60_RS17115 (3520023) 3520023..3520913 + 891 WP_000971336.1 heme o synthase -
QCL60_RS17120 (3521098) 3521098..3521409 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
QCL60_RS17125 (3521393) 3521393..3521935 + 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
QCL60_RS17130 (3521991) 3521991..3522926 - 936 WP_001297127.1 tetratricopeptide repeat protein -
QCL60_RS17135 (3523334) 3523334..3524698 + 1365 WP_001000999.1 MFS transporter -
QCL60_RS17140 (3524826) 3524826..3525317 - 492 WP_001138904.1 nucleotide binding protein YajQ -
QCL60_RS17145 (3525485) 3525485..3526396 + 912 WP_000705847.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T277150 WP_000227784.1 NZ_CP122517:3521393-3521935 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT277150 WP_001297137.1 NZ_CP122517:3521098-3521409 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References