Detailed information of TA system TA027715

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-YefM
• Location: 4773197..4773702
• Replicon: chromosome
• Accession: NC_017770
• Organism: Solitalea canadensis DSM 3403

Toxin (Protein)

• Gene name: relE
• Uniprot ID: H8KN14
• Locus tag: SOLCA_RS20105
• Protein ID: WP_014682315.1
• Coordinates: 4773448..4773702 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: H8KN13
• Locus tag: SOLCA_RS20100
• Protein ID: WP_014682314.1
• Coordinates: 4773197..4773451 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SOLCA_RS20090	4768554..4771382	-	2829	WP_014682312.1	DNA polymerase I	-
SOLCA_RS20095	4771619..4773112	+	1494	WP_014682313.1	histidine ammonia-lyase	-
SOLCA_RS20100	4773197..4773451	+	255	WP_014682314.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
SOLCA_RS20105	4773448..4773702	+	255	WP_014682315.1	Txe/YoeB family addiction module toxin	Toxin
SOLCA_RS20110	4773736..4774305	-	570	WP_014682316.1	D-sedoheptulose 7-phosphate isomerase	-
SOLCA_RS20115	4774381..4775607	-	1227	WP_157604614.1	PQQ-dependent sugar dehydrogenase	-
SOLCA_RS20120	4775686..4776654	-	969	WP_014682318.1	6-phosphofructokinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10241.86 Da
• Isoelectric Point: 9.4092

>T27715 WP_014682315.1 NC_017770:4773448-4773702 [Solitalea canadensis DSM 3403]
MKIVFLSDAWDDYLFWQLTDKIILKKINNLIKEIERQPYDGNGKPEPLKHNLAGWRSRRINLEHRLVYRIDNDSIIVLQC
RYHY

Nucleotide

• Length: 255 bp

>T27715 NC_017770:4773448-4773702 [Solitalea canadensis DSM 3403]
ATGAAGATTGTTTTTTTAAGTGACGCATGGGATGATTATCTGTTTTGGCAATTGACAGATAAAATAATCCTCAAAAAAAT
TAACAACCTGATAAAAGAAATTGAAAGACAACCTTACGATGGCAACGGAAAACCTGAACCATTAAAGCATAATTTGGCTG
GTTGGAGGTCTCGTAGAATAAACCTGGAACATCGTCTTGTTTATCGGATAGACAATGATTCTATAATCGTTTTACAATGC
AGATATCATTATTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9799.08 Da
• Isoelectric Point: 5.0644

>AT27715 WP_014682314.1 NC_017770:4773197-4773451 [Solitalea canadensis DSM 3403]
MEITTYSYFRQNLKTFLDKVLSSHSPLFVTRNNGEDVVVLSKSDYESMQETFYLLKSPNNALRLLKGIDEYNKGMGQQRD
LIEE

Nucleotide

• Length: 255 bp

>AT27715 NC_017770:4773197-4773451 [Solitalea canadensis DSM 3403]
ATGGAAATTACAACGTACTCATACTTCAGGCAAAACCTTAAGACATTCCTTGATAAGGTTTTATCAAGTCATTCGCCCTT
ATTTGTTACGAGGAATAATGGTGAAGATGTAGTAGTTCTGTCAAAGTCTGACTATGAAAGCATGCAAGAAACTTTTTACT
TGCTTAAGAGTCCAAACAATGCACTCCGACTATTAAAAGGCATAGATGAATATAATAAAGGCATGGGGCAACAGCGGGAT
TTAATTGAAGAATGA

Structures

Toxin

• AlphaFold DB: H8KN14

Antitoxin

• AlphaFold DB: H8KN13