Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3487021..3487639 Replicon chromosome
Accession NZ_CP122517
Organism Escherichia coli strain MY1-8

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QCL60_RS16955 Protein ID WP_001291435.1
Coordinates 3487421..3487639 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QCL60_RS16950 Protein ID WP_000344800.1
Coordinates 3487021..3487395 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCL60_RS16940 (3482110) 3482110..3483303 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QCL60_RS16945 (3483326) 3483326..3486475 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QCL60_RS16950 (3487021) 3487021..3487395 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QCL60_RS16955 (3487421) 3487421..3487639 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QCL60_RS16960 (3487811) 3487811..3488362 + 552 WP_000102568.1 maltose O-acetyltransferase -
QCL60_RS16965 (3488478) 3488478..3488948 + 471 WP_000136192.1 YlaC family protein -
QCL60_RS16970 (3489112) 3489112..3490662 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QCL60_RS16975 (3490704) 3490704..3491057 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QCL60_RS16985 (3491436) 3491436..3491747 + 312 WP_000409911.1 MGMT family protein -
QCL60_RS16990 (3491778) 3491778..3492350 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T277149 WP_001291435.1 NZ_CP122517:3487421-3487639 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT277149 WP_000344800.1 NZ_CP122517:3487021-3487395 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References