Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1344142..1344767 Replicon chromosome
Accession NZ_CP122517
Organism Escherichia coli strain MY1-8

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QCL60_RS06570 Protein ID WP_000911330.1
Coordinates 1344369..1344767 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag QCL60_RS06565 Protein ID WP_000450524.1
Coordinates 1344142..1344369 (+) Length 76 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCL60_RS06540 (1339945) 1339945..1340415 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
QCL60_RS06545 (1340415) 1340415..1340987 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
QCL60_RS06550 (1341133) 1341133..1342011 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
QCL60_RS06555 (1342028) 1342028..1343062 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
QCL60_RS06560 (1343275) 1343275..1343988 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
QCL60_RS06565 (1344142) 1344142..1344369 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
QCL60_RS06570 (1344369) 1344369..1344767 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
QCL60_RS06575 (1344914) 1344914..1345777 + 864 WP_001267508.1 neutral zinc metallopeptidase -
QCL60_RS06580 (1345792) 1345792..1347807 + 2016 WP_000829329.1 tRNA cytosine(34) acetyltransferase TmcA -
QCL60_RS06585 (1347881) 1347881..1348579 + 699 WP_000679823.1 esterase -
QCL60_RS06590 (1348689) 1348689..1348889 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-125)

Antitoxin

(7-52)


Sequences


Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T277140 WP_000911330.1 NZ_CP122517:1344369-1344767 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp


Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT277140 WP_000450524.1 NZ_CP122517:1344142-1344369 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References