Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1668760..1669428 Replicon chromosome
Accession NC_017769
Organism Streptococcus pneumoniae ST556

Toxin (Protein)


Gene name hicA Uniprot ID C1C927
Locus tag MYY_RS08730 Protein ID WP_001132282.1
Coordinates 1669249..1669428 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag MYY_RS08725 Protein ID WP_000961810.1
Coordinates 1668760..1669212 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYY_RS08705 1665609..1666643 - 1035 WP_000747916.1 ATP-binding protein -
MYY_RS08710 1666753..1666911 - 159 WP_000418159.1 7,8-dihydro-8-oxoguanine-triphosphatase -
MYY_RS08715 1666892..1667980 - 1089 WP_000719711.1 M50 family metallopeptidase -
MYY_RS08720 1667999..1668469 - 471 WP_000257114.1 DUF3013 family protein -
MYY_RS08725 1668760..1669212 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MYY_RS08730 1669249..1669428 - 180 WP_001132282.1 type II toxin-antitoxin system HicA family toxin Toxin
MYY_RS08735 1669565..1669744 - 180 WP_001048906.1 hypothetical protein -
MYY_RS08740 1669909..1670148 - 240 WP_000818079.1 hypothetical protein -
MYY_RS08745 1670418..1671689 + 1272 WP_001113206.1 replication-associated recombination protein A -
MYY_RS08755 1672236..1673555 - 1320 WP_000502563.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.95 Da        Isoelectric Point: 11.0174

>T27714 WP_001132282.1 NC_017769:c1669428-1669249 [Streptococcus pneumoniae ST556]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERLITIPHGELNKYTERGIRKQAGL

Download         Length: 180 bp

>T27714 NC_017769:c1669428-1669249 [Streptococcus pneumoniae ST556]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAGAAGCAAGGGGAAAGACTTATCACAATCCCTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT27714 WP_000961810.1 NC_017769:c1669212-1668760 [Streptococcus pneumoniae ST556]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT27714 NC_017769:c1669212-1668760 [Streptococcus pneumoniae ST556]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACTATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E7SUI3

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References