277133

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 1145747..1146371 Replicon chromosome
Accession NZ_CP122515
Organism Helicobacter pylori strain HP22

Toxin (Protein)


Gene name relE Uniprot ID A0A2A6UH71
Locus tag QCM05_RS05590 Protein ID WP_025455067.1
Coordinates 1146105..1146371 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag QCM05_RS05585 Protein ID WP_279962694.1
Coordinates 1145747..1146124 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QCM05_RS05560 (QCM05_05560) 1140965..1142077 + 1113 WP_279962692.1 hydrogenase formation protein HypD -
QCM05_RS05565 (QCM05_05565) 1142028..1142688 - 661 Protein_1073 hypothetical protein -
QCM05_RS05580 (QCM05_05580) 1143061..1145286 + 2226 WP_279962693.1 Hop family adhesin BabA -
QCM05_RS05585 (QCM05_05585) 1145747..1146124 + 378 WP_279962694.1 hypothetical protein Antitoxin
QCM05_RS05590 (QCM05_05590) 1146105..1146371 + 267 WP_025455067.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
QCM05_RS05595 (QCM05_05595) 1146476..1147000 - 525 WP_279962696.1 acyl-CoA thioesterase -
QCM05_RS05600 (QCM05_05600) 1147147..1147995 + 849 WP_279962697.1 SDR family oxidoreductase -
QCM05_RS05605 (QCM05_05605) 1147988..1148968 + 981 WP_279962699.1 iron ABC transporter permease -
QCM05_RS05610 (QCM05_05610) 1148968..1149735 + 768 WP_024422093.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10303.17 Da        Isoelectric Point: 9.6292

>T277133 WP_025455067.1 NZ_CP122515:1146105-1146371 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNKVILSLRKKEPLDPQFQDHALKGKWKPFRECHIKADILLVYLVKDDELILVR
LGSHSELF

Download         Length: 267 bp

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14832.90 Da        Isoelectric Point: 9.0112

>AT277133 WP_279962694.1 NZ_CP122515:1145747-1146124 [Helicobacter pylori]
MPNSPTKKDYTRYSEKQLFNLINQLERKIKKMQNDRASFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCL
GRKIPNLETQQAMRDVLNKETDLIVEDFSSYSDERKRVLGVETQP

Download         Length: 378 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A6UH71

Antitoxin

Source ID Structure

References