Detailed information of TA system TA277132

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 581599..582790
• Replicon: chromosome
• Accession: NZ_CP122515
• Organism: Helicobacter pylori strain HP22

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: QCM05_RS02830
• Protein ID: WP_140446210.1
• Coordinates: 582026..582790 (+)
• Length: 255 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: QCM05_RS02825
• Protein ID: WP_120824146.1
• Coordinates: 581599..582036 (+)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QCM05_RS02815 (QCM05_02815)	580318..580797	+	480	WP_279963382.1	reverse transcriptase domain-containing protein	-
QCM05_RS02820 (QCM05_02820)	580855..581373	+	519	WP_001869765.1	hypothetical protein	-
QCM05_RS02825 (QCM05_02825)	581599..582036	+	438	WP_120824146.1	Panacea domain-containing protein	Antitoxin
QCM05_RS02830 (QCM05_02830)	582026..582790	+	765	WP_140446210.1	hypothetical protein	Toxin
QCM05_RS02835 (QCM05_02835)	583015..584202	-	1188	WP_279963384.1	transcription termination factor NusA	-
QCM05_RS02840 (QCM05_02840)	584290..585450	-	1161	WP_279963385.1	aminotransferase class V-fold PLP-dependent enzyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (24-119)

Sequences

Toxin

Protein

• Length: 255 a.a.
• Molecular weight: 29805.00 Da
• Isoelectric Point: 8.8819

>T277132 WP_140446210.1 NZ_CP122515:582026-582790 [Helicobacter pylori]
MEIKEEDKDKKLEKIIVLLCEKGDLSSQKDQIIKDLKEIYKGEYKHKYSKITTIILNSTRDKEQAFMMLTQNIKTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDVSIKLEDELNKNYKKLSEELNKQQTQYITILGIFASIVLTFV
GGLAFSTSVLSNIDKANAYRLVFVMAFIALFFGNILYLLFSFLSKISLSEEKKDKQENFFKKPIFWFNLIVTILFVIGFC
GELHIIQRLASKYF

Nucleotide

• Length: 765 bp

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 17300.42 Da
• Isoelectric Point: 6.1265

>AT277132 WP_120824146.1 NZ_CP122515:581599-582036 [Helicobacter pylori]
MVNTLELAKYILKHSNKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVAREVYYEYRNYGANSIDKPKEETL
SQDLREDELETINRSIKKCNEKSYWDLVKESHKEDGAWHKSFKEDRKEIISKDLIKQEAKQANGN

Nucleotide

• Length: 438 bp