Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 11870..12392 Replicon plasmid unnamed7
Accession NZ_CP122514
Organism Escherichia coli strain W444

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag QC806_RS27215 Protein ID WP_284632255.1
Coordinates 12111..12392 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag QC806_RS27210 Protein ID WP_000121743.1
Coordinates 11870..12121 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC806_RS27190 7993..8346 - 354 WP_024129958.1 DNA distortion polypeptide 3 -
QC806_RS27195 8483..8929 - 447 WP_001074384.1 hypothetical protein -
QC806_RS27200 8933..9775 - 843 WP_000435064.1 replication initiation protein -
QC806_RS27205 9796..10635 - 840 WP_024129959.1 replication initiation protein -
QC806_RS27210 11870..12121 + 252 WP_000121743.1 plasmid stabilization protein Antitoxin
QC806_RS27215 12111..12392 + 282 WP_284632255.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QC806_RS27220 12631..12723 - 93 Protein_18 IS6 family transposase -
QC806_RS27225 12995..14080 - 1086 Protein_19 IS91 family transposase -
QC806_RS27230 14090..14278 - 189 WP_000957857.1 hypothetical protein -
QC806_RS27235 14398..15828 + 1431 Protein_21 IS4-like element IS50R family transposase -
QC806_RS27240 15857..16651 + 795 WP_000572405.1 aminoglycoside O-phosphotransferase APH(3')-IIa -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaOXA-1 / catB3 / ARR-3 / qacE / aph(3')-IIa / qnrS2 - 1..26284 26284
- inside Integron catB3 / qacE / blaOXA-1 / ARR-3 - 2..26282 26280


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11049.95 Da        Isoelectric Point: 10.5938

>T277131 WP_284632255.1 NZ_CP122514:12111-12392 [Escherichia coli]
MTYELAFDRRALKEWQKLGHTIREQFKKKLAERLENPRVPAARLHGHADRYKIKLRALGYRLVYQVIDEKVVLLVIAVGR
RESSEVYQIADMR

Download         Length: 282 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9194.43 Da        Isoelectric Point: 4.1683

>AT277131 WP_000121743.1 NZ_CP122514:11870-12121 [Escherichia coli]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPKLYAYYRELAEDAELNAVADERMKNPEIVKVNL
DDL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References