Detailed information of TA system TA027712

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 757688..758274
• Replicon: chromosome
• Accession: NC_017768
• Organism: Streptococcus mutans LJ23

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: SMULJ23_RS03690
• Protein ID: WP_002265423.1
• Coordinates: 757688..757879 (+)
• Length: 64 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: SMULJ23_RS03695
• Protein ID: WP_002264915.1
• Coordinates: 757897..758274 (+)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SMULJ23_RS03675	755732..756598	+	867	WP_014677910.1	type II CRISPR-associated endonuclease Cas1	-
SMULJ23_RS03680	756595..756939	+	345	WP_044560427.1	CRISPR-associated endonuclease Cas2	-
SMULJ23_RS03685	756929..757591	+	663	WP_002263546.1	type II-A CRISPR-associated protein Csn2	-
SMULJ23_RS03690	757688..757879	+	192	WP_002265423.1	type II toxin-antitoxin system HicA family toxin	Toxin
SMULJ23_RS03695	757897..758274	+	378	WP_002264915.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
SMULJ23_RS03700	759140..760033	-	894	WP_002276322.1	XRE family transcriptional regulator	-
SMULJ23_RS03705	760348..760632	+	285	WP_044560428.1	helix-turn-helix transcriptional regulator	-
SMULJ23_RS03710	760795..762546	+	1752	WP_014677913.1	LPXTG cell wall anchor domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-61)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (5-107)

Sequences

Toxin

Protein

• Length: 64 a.a.
• Molecular weight: 7177.52 Da
• Isoelectric Point: 10.7089

>T27712 WP_002265423.1 NC_017768:757688-757879 [Streptococcus mutans LJ23]
MPLTGKELARLAINNGWEEVRVRGSHHHFKKDGVPYIVTIPIHGNKVLKIGLEKKLLRDLNLL

Nucleotide

• Length: 192 bp

>T27712 NC_017768:757688-757879 [Streptococcus mutans LJ23]
TTGCCATTAACAGGGAAAGAATTAGCTAGATTAGCGATAAACAATGGATGGGAAGAAGTTCGGGTGAGAGGAAGTCATCA
TCATTTCAAGAAAGATGGAGTACCTTATATTGTGACGATTCCCATTCATGGAAATAAAGTGCTTAAAATTGGTCTTGAAA
AGAAACTCTTAAGGGATTTAAATTTATTATGA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 14307.31 Da
• Isoelectric Point: 4.5628

>AT27712 WP_002264915.1 NC_017768:757897-758274 [Streptococcus mutans LJ23]
MLKTYPAIFHKEEEGYWVEFPEFGGGTQGEDLEEAMKNARQMLESVLASYLDEGMKLPNPSEIRKLSVEDGFATMIQADP
NPYLKNNKAIRKNVTVPEWLVQLADRDQVNYSEVLTKALEKKLQL

Nucleotide

• Length: 378 bp

>AT27712 NC_017768:757897-758274 [Streptococcus mutans LJ23]
ATGTTAAAAACATATCCTGCAATTTTTCATAAGGAAGAGGAAGGATATTGGGTTGAATTTCCTGAATTTGGCGGTGGTAC
GCAAGGGGAAGATTTGGAAGAAGCCATGAAGAACGCTCGTCAGATGTTAGAAAGTGTATTGGCCTCCTATCTAGATGAGG
GAATGAAACTGCCTAATCCAAGTGAGATAAGGAAACTATCTGTTGAAGATGGCTTTGCAACTATGATTCAAGCAGATCCT
AATCCTTATCTCAAAAATAACAAAGCTATTCGAAAGAATGTTACCGTACCTGAGTGGCTAGTACAATTAGCAGATCGTGA
TCAAGTGAATTATTCTGAAGTATTAACAAAGGCTTTGGAAAAGAAACTACAATTATAA