Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 96119..97742 Replicon plasmid unnamed1
Accession NZ_CP122508
Organism Escherichia coli strain W444

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag QC806_RS23710 Protein ID WP_000088046.1
Coordinates 96417..97742 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag QC806_RS23705 Protein ID WP_024136327.1
Coordinates 96119..96412 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC806_RS23675 91991..93232 + 1242 WP_001053338.1 VWA domain-containing protein -
QC806_RS23680 93323..93454 + 132 WP_000374059.1 hypothetical protein -
QC806_RS23685 93795..94076 - 282 WP_000077926.1 hypothetical protein -
QC806_RS23690 94126..94317 - 192 WP_000398480.1 hypothetical protein -
QC806_RS23695 94409..94750 - 342 WP_001151575.1 hypothetical protein -
QC806_RS23700 95123..95515 + 393 WP_000341066.1 hypothetical protein -
QC806_RS23705 96119..96412 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
QC806_RS23710 96417..97742 + 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
QC806_RS23715 97803..98009 + 207 WP_000134171.1 hypothetical protein -
QC806_RS23720 98111..98521 + 411 WP_000985911.1 hypothetical protein -
QC806_RS23725 98534..99349 + 816 WP_001572439.1 HNH endonuclease signature motif containing protein -
QC806_RS23730 99603..100028 + 426 WP_001043843.1 hypothetical protein -
QC806_RS23735 100577..100885 + 309 WP_001224687.1 hypothetical protein -
QC806_RS23740 100901..101758 + 858 WP_000784387.1 HNH endonuclease signature motif containing protein -
QC806_RS23745 101820..102023 + 204 WP_001194555.1 hypothetical protein -
QC806_RS23750 102365..102721 - 357 WP_065311124.1 H-NS family nucleoid-associated regulatory protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid tet(A) / qnrS1 / dfrA12 / aadA2 / cmlA1 / ant(3'')-Ia / sul3 / mef(B) / aph(3')-Ia - 1..247590 247590


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T277116 WP_000088046.1 NZ_CP122508:96417-97742 [Escherichia coli]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT277116 WP_024136327.1 NZ_CP122508:96119-96412 [Escherichia coli]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References