Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 4211176..4211774 Replicon chromosome
Accession NZ_CP122507
Organism Escherichia coli strain W444

Toxin (Protein)


Gene name doc Uniprot ID A0A8T6PRV3
Locus tag QC806_RS20765 Protein ID WP_053291281.1
Coordinates 4211176..4211553 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID L4J1C0
Locus tag QC806_RS20770 Protein ID WP_001603498.1
Coordinates 4211553..4211774 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QC806_RS20735 (4206400) 4206400..4206738 + 339 WP_000883400.1 divalent cation tolerance protein CutA -
QC806_RS20740 (4206714) 4206714..4208411 + 1698 WP_000068922.1 protein-disulfide reductase DsbD -
QC806_RS20745 (4208448) 4208448..4209023 + 576 WP_001188520.1 transcriptional regulator -
QC806_RS20755 (4209403) 4209403..4210665 + 1263 WP_096263470.1 integrase arm-type DNA-binding domain-containing protein -
QC806_RS20760 (4210851) 4210851..4211066 + 216 Protein_4056 transposase -
QC806_RS20765 (4211176) 4211176..4211553 - 378 WP_053291281.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
QC806_RS20770 (4211553) 4211553..4211774 - 222 WP_001603498.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QC806_RS20775 (4211959) 4211959..4212978 - 1020 WP_219398756.1 fimbrial protein -
QC806_RS20780 (4212990) 4212990..4215476 - 2487 WP_096261919.1 fimbrial biogenesis outer membrane usher protein -
QC806_RS20785 (4215494) 4215494..4216174 - 681 WP_063100857.1 fimbrial assembly chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4210851..4224201 13350
- flank IS/Tn - - 4210851..4211132 281


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(4-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13487.28 Da        Isoelectric Point: 6.2257

>T277113 WP_053291281.1 NZ_CP122507:c4211553-4211176 [Escherichia coli]
MRHISPEELIAIHDANISRYGGLPGMPDSGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVYDSPELAELTVGAATGEVSVSTVVATLRRLYGTA

Download         Length: 378 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8190.24 Da        Isoelectric Point: 6.3159

>AT277113 WP_001603498.1 NZ_CP122507:c4211774-4211553 [Escherichia coli]
MQSINFRTARSNLTEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDTTNKKLVNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB L4J1C0

References